Peak Fronting, Column Life and Column Conditioning
Although there are other possible causes, the most common source of fronting peaks is a disturbance in the column packing bed. The fix is straightforward: replace the column.
Peak Fronting, Column Life, and Column Conditioning By Ryan D. Morrison and John W. Dolan
The authors look at three column performance problems encountered frequently in today's laboratory.
Reversed-Phase LC in 100% Water
How can you avoid phase collapse when 5% organic solvent is too strong?