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© 2021 MJH Life Sciences™ and Chromatography Online. All rights reserved.
Six nitrosamines are separated using a YMC-Triart C18 UHPLC column. This is challenging due to the commonly observed small peaks thanks to low impurity concentrations.
Mipomersen (Kynamro®) is used as a model for the analysis of antisense oligonucleotides (ASOs) using LC-HRMS. The YMC-Triart C8 metal-free column used is an excellent choice for oligonucleotides.