LCGC Europe-01-01-2021

Untargeted LC–MS Lipidomics with Data Independent Acquisition using Sequential Window Acquisition of All Theoretical Fragment-Ion Spectra

January 01, 2021

Peer Reviewed

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A focus on untargeted UHPLC–MS/MS lipidomics with data independent acquisition using SWATH technology. This article explores the wide-ranging potential and peculiarities of SWATH–MS hyphenated with UHPLC for the profiling of lipidomes of various biological samples.

Liquid Chromatography Troubleshooting Odds and Ends from 2020

January 01, 2021

LC Troubleshooting

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Sometimes our approach to troubleshooting specific problems has to change in response to changes in high performance liquid chromatography (HPLC) technology over time. In this installment, we discuss changes in technologies for mobile-phase degassing, silica-based stationary phases, and models for reversed-phase selectivity.

What Chromatograms Can Tell Us About Our Analytes

January 01, 2021

GC Connections

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Many chromatographic methods are automatically performed by today’s data systems, yet trace their origins to early, simpler techniques. This piece discusses how our data systems both assist and hinder in obtaining maximum information from chromatograms.

Turning Up the Heat – The Effect of Temperature on Analytical Extractions

January 01, 2021

Sample Preperation Perspectives

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Temperature impacts solubility, diffusion, surface tension, and more. It can potentially lead to solute decomposition. This month we will explore the role of temperature in analytical extractions.