LCGC Europe-03-11-2021

Non-aqueous Ion-Exchange Chromatography Using High Acid-base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates

March 11, 2021

Peer Reviewed

34

3

Ion-exchange chromatography (IEX) is a frequently overlooked technique. This novel IEX method uses non-aqueous mobile phases to purify a non-crystalline intermediate after a reductive amination with D-xylose. IEX delivers a step change in strength and purity of the intermediate allowing successful downstream processing.