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Special Issues-05-01-2020

Special Issues

Optimized Explosives Analysis Using Portable Gas Chromatography–Mass Spectrometry for Battlefield Forensics

May 01, 2020

Articles

18

2

When explosives are encountered on the battlefield, the use of portable GC–MS is valuable for the detection and confirmatory identification of pre- and post-detonation threats. In addition, this technique provides information about the source of explosives based on the detection and identification of trace-level chemicals in the sample. The data presented here confirm this capability.

Nontargeted Screening as an Essential Tool for Drinking Water Quality Monitoring

May 01, 2020

Articles

18

2

Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) is used in combination with a comprehensive data analysis workflow to screen water samples for potentially hazardous transformation products from organic micropollutants to determine the efficacy of different water treatment methods.

Aggregate and Fragment Analysis in Therapeutic Monoclonal Antibodies Using On-Line Size-Exclusion Chromatography with Native Mass Spectrometry

May 01, 2020

Articles

18

2

Size-exclusion chromatography (SEC), with the use of ammonium acetate buffer, can be coupled on-line to electrospray ionization MS for the characterization of size variants of therapeutic monoclonal antibodies (mAbs). A quadrupole time-of-flight (QTOF) MS system was employed, and the MS method was optimized to achieve favorable sensitivity for high-mass detection, while maintaining the structural integrity of the aggregates (or high molecular weight species) and fragments (or low molecular weight species).