Special Issues-05-01-21

A Quick Approach to Screen Oligomers from Extractables Studies Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry (LC–QTOF-MS)

May 01, 2021

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Analysis of extractables and leachables (E&L) from plastic packaging is of great importance for pharmaceutical product safety. Accurate and rapid identification of unknown compounds in E&L is often complex and challenging. To address this challenge, we demonstrate a quick method for oligomer determination using LC–QTOF-MS.

Laser Desorption Postionization Mass Spectrometry

May 01, 2021

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Supplementing short pulse lasers with laser postionization increases ionization yields for desorption and ablation of solid samples in mass spectrometry. Here, we give an overview of the mechanisms and technical requirements for molecular photoionization in femtosecond (fs) laser desorption postionization mass spectrometry (LDPI-MS).

Six Key Differentiators Between Liquid Chromatography and High-Resolution Ion Mobility

May 01, 2021

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Using ion mobility, analytes that have the same molecular mass can be separated by their shape, centers of mass, and collision cross section, but challenges such as ion loss can still occur. A new development in ion mobility separation, high-resolution ion mobility (HRIM), addresses such problems, and is particularly well suited to challenging applications, such as glycosylation monitoring of biological drugs and vitamin D analysis.

Breaking the Rules: Two- and Three-Dimensional Chromatography with Four Dimensions of Mass Spectrometry

May 01, 2021

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Two-dimensional liquid chromatography (2D-LC) allows much greater resolution of peaks than is possible in a classical single dimensional separation. For the next development in separations, we employed 2D-LC in two highly orthogonal dimensions of separation with four mass spectrometers for detection, with parallel detection in each dimension. We have further broken ground by using three dimensions of separation with four mass spectrometers, using two parallel second dimensions.