Special Issues-06-01-2015

Click the title above to open the LCGC Europe June 2015 Recent Developments in HPLC and UHPLC Supplement, Vol 28, No s6, in an interactive PDF format.

Special Issues

June 01, 2015

Introduction from the Guest Editor.

This article explains how statistical overlap theory can be applied to chromatography in everyday usage.

A liquid chromatography–electrospray ionization tandem mass spectrometry (LC–ESI–MS–MS) method has been developed to determine multiple preservatives in cosmetics and personal care products.

The capabilities of enhanced-fluidity liquid chromatography for highly polar compounds is described and the value of using the entire continuum of 0–100% carbon dioxide solvent systems is discussed in terms of changes in mobile‑phase properties and applications.

A novel approach to enhancing the selectivity of ionizable compounds using superficially porous particles that are stable in a wider pH range is reported here.

Internal standard methods are used to improve the precision and accuracy of results where volume errors are difficult to predict and control. A systematic approach has been used to compare internal and external standard methods in high performance liquid chromatography (HPLC). The precision was determined at several different injection volumes for HPLC and ultrahigh‑pressure liquid chromatography (UHPLC), with two analyte and internal standard combinations. Precision using three methods of adding the internal standard to the analyte before final dilution was examined. The internal standard method outperformed external standard methods in all instances.