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Special Issues-06-01-2018

Special Issues

Vol 36 No s6 LCGC North America June 2018 LC Column Technology Supplement PDF

June 01, 2018

Issue PDF

36

6

Click the title above to open the LCGC North America June 2018 regular issue in an interactive PDF format.

Current and Future Chromatographic Columns: Is One Column Enough to Rule Them All?

June 01, 2018

Articles

36

6

The packed particle bed format still rules LC columns, but advances continue in monoliths. Meanwhile, newer formats are on the horizon, including microfabricated columns and 3D printed columns. This article provides a critical review of all these technologies and demonstrates how further development of chromatographic columns will be of paramount importance in the future.

Designing Vacuum-Jacketed User-Friendly Columns for Maximum Resolution Under Extreme UHPLC and SFC Conditions

June 01, 2018

Articles

36

6

Thermal effects in UHPLC and low-density SFC cause peak broadening and distortion. A solution to this problem is to thermally insulate the chromatographic column. Vacuum-jacketed column technology has been developed as a new approach to insulate the column in a practical way.

Bioinert Versus Biocompatible: The Benefits of Different Column Materials in Liquid Chromatography Separations

June 01, 2018

Articles

36

6

In this study, we compare the performance of plastic and metal materials in UHPLC columns designed for the analysis of biological molecules. We evaluate the performance of these materials in terms of inertness, column chromatographic performance, and reproducibility.

The Use of HILIC Zwitterionic Phase Superficially Porous Particles for Metabolomics Analysis

June 01, 2018

Articles

36

6

This article highlights the use of a new HILIC zwitterionic phase on superficially porous particles. A study on the use of a novel mobile-phase additive to achieve superior peak shape and isomer separation is also discussed, as well as improved LC–MS detection capabilities for metabolomics analysis.