Special Issues-06-01-2021

Non-Targeted Analysis of PFAS in Surface Water Using Fragment Ion Flagging

June 01, 2021

39

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Per- and polyfluoroalkyl substances (PFAS) in surface water have become a major concern due to their persistency and toxicity. We recently spoke to Stefan Van Leeuwen and Bjorn Berendsen of Wageningen Food Safety Research (WFSR), in The Netherlands, about their novel research into non-targeted PFAS screening using an LC–HRMS method with fragment ion flagging.

Ion Mobility–Mass Spectrometry (IM–MS): Enhancing Performance of Analytical Methods

June 01, 2021

39

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Modern ion mobility–mass spectrometry (IM–MS) is a key separation technology for detailed molecular characterization studies and also as part of emerging data acquisition strategies for demanding small molecule and several applications. Here is what you need to know.

The Role of Adsorption and pH of the Mobile Phase on the Chromatographic Behavior of a Therapeutic Peptide

June 01, 2021

39

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We explore the impact of two different stationary phases and ion-pair reagents on the retention behavior of a therapeutic peptide using reversed-phase liquid chromatography. This information is of fundamental importance for the development of reliable, selective, and fast analytical methods able to separate and identify the target peptide.

An Ant-Man Perspective for Chromatography: My Stochastic World

June 01, 2021

39

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The stochastic theory of chromatography allows one to connect mathematics to separation science in an intelligible form. We take a “walk” through the column at the level of an Ant-Man, where we can see that chromatography is mathematics and mathematics is chromatography!