Special Issues-10-03-2015

Special Issues

MS Detection of Waste in Public Swimming Facilities

October 03, 2015

Articles

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Is your swimming pool clean and safe? Recreational water illness, most commonly in the form of digestive tract illness or skin, ear, or respiratory infections, is often caused by water contamination. The authors present a robust method, using solid-phase extraction and high-resolution mass spectrometry, for monitoring swimming pool water.

What’s the Most Meaningful Standard for Mass Spectrometry: Instrument Detection Limit or Signal-to-Noise Ratio?

October 01, 2015

Articles

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When evaluating the performance of mass spectrometers, one needs to consider the best (or most meaningful) figure of merit to use; options include instrument detection limit (IDL) and signal-to-noise ratio (S/N). In the last 15 years, vendor specifications for S/N have increased from 10:1 to greater than 100,000:1. Does that accurately reflect improvements in mass spectrometers? Although there have been many significant changes, the change in S/N specifications has been far greater than the corresponding change in method detection limits (MDL). Under appropriate conditions, S/N is a meaningful standard, but the value of any S/N must be evaluated in context of the chromatography and sample. Factors influencing the validity of vendor S/N specifications are reviewed, and the statistical alternative of IDL is presented as a replacement that is more consistent with regulatory guidelines and a more relevant indicator of instrument performance.

Combining Thermal Desorption GC and TOF-MS for the Determination of Melon VOC Profiles

October 01, 2015

Articles

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A method based on thermal desorption with gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS) can elucidate how key volatiles vary with the size of the melon pieces. Such analytical information is of value in efforts to improve the quality and safety of ready-to-eat foods.

Solid-Phase Extraction of US EPA 535 for Chloroacetanilide and Acetamide Degradates in Drinking Water Samples Prior to Liquid Chromatography/Tandem Mass Spectrometry

October 01, 2015

Sponsored Application Notes

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The US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants.

Comprehensive Multilevel Characterization of Biologics Using Sheathless Capillary Electrophoresis Hyphenated to Tandem Mass Spectrometry

October 01, 2015

Articles

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An analytical methodology for the characterization of the primary structure of biotherapeutic proteins using sheathless CE–ESI-MS-MS instrumentation is presented. For the first time, complete sequence coverage can be achieved using a bottom-up proteomic approach from a single analysis of a tryptic digest. In a biosimilarity assessment, a single amino acid substitution was detected.

Vol 13 No 4 Current Trends in Mass Spectrometry October 2015 Issue PDF

October 01, 2015

Issue PDF

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Click the title above to open the October 2015 issue of Current Trends in Mass Spectrometry, Volume 13, Number 4, in an interactive PDF format.