Special Issues-10-09-2020

From the Editor

October 09, 2020

An introduction from guest editors, Koen Sandra and Davy Guillarme, on this special supple-ment from LCGC Europe focusing on recent developments in biopharmaceutical analysis.

The diverse nature of oligonucleotide therapeutics leads to the requirement for multiple separation methods to characterize quality attributes. Highly chemically-modified to improve efficacy and resilience to nucleases, they are challenging to analyse using a single method. This article discusses multiple chromatographic separation methods, and the benefits of mass spectrometry (MS).

This article explores the potential of microchip capillary electrophoresis–mass spectrometry (CE–MS) for the characterization of intact biopharmaceuticals, and how this technique can effectively be employed to monitor essential quality attributes of interest.