Pushing the Limits of Small Molecule Structural Characterization with High-Resolution Ion Mobility (HRIM)

Event Overview:

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful analytical technique for qualitative and quantitative analysis of small molecules including drugs. Recent technological advances, such as the development of Structures for Lossless Ion Manipulations (SLIM) high-resolution ion mobility (HRIM), have significantly progressed structural characterization capabilities while also offering substantial improvement in throughput due to the rapid nature of the gas-phase separations. This presentation will highlight recent developments in HRIM applications to a range of biologically, clinically, and pharmaceutically relevant small molecules including new psychoactive substances like fentanyl analogs and synthetic cannabinoids. A special emphasis will be on differentiation and identification of isomeric species (i.e., stereoisomers, prototropic isomers, atropisomers, etc.).

Key Learning Objectives:

Advantages of ion mobility-mass spectrometry (IM-MS) for analysis of small molecules
Implementation of IM with existing analytical methods (i.e., LC-MS workflows)
Benefits of high-resolution IM techniques for rapid structural characterization of drug isomers

Who Should Attend:

Principal Investigator
Lab Director
Scientist
Core Facility Director
Post Doc

Featured Speakers:

Christopher Chouinard

Assistant Professor

Clemson University

Dr. Christopher Chouinard received his Ph.D. from the University of Florida and did post-doctoral training at Pacific Northwest National Laboratory (PNNL). He has been an Assistant Professor at Clemson University since 2022, and his group develops ion mobility-mass spectrometry (IM-MS) methods and technology for a variety of bioanalytical applications.

Speaker's LinkedIn: https://www.linkedin.com/in/christopher-chouinard-57224b41/
Speaker's Email: cchouin@clemson.edu

For any technical questions please contact Jorge de la Bandera: jdelabandera@mjhlifesciences.com

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Pushing the Limits of Small Molecule Structural Characterization with High-Resolution Ion Mobility (HRIM)

Thu, Apr 4, 2024 11:00 AM EDT{LOCAL_TZ}

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