Analyzing the Method Lifecycle of SFC Methods: An HTC-18 Interview with Claudio Brunelli

At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Claudio Brunelli following his talk entitled: Analytical Method Lifecycle of SFC Methods from Development to QC and Commercialization in Pharmaceutical Development.

Claudio Brunelli has more than 20 years of experience in Analytical Research and Development in Pharmaceutical industry, and is a separation scientist supporting chromatographic method development, method troubleshooting, validation and transfer to quality control (QC). He also covers other areas such as forced degradation and drug stability. After completing his PhD with Professor Carlo Bicchi at Universita’ degli Studi di Torino in Italy on Chiral GC, Fast and Ultrafast GC he completed a Postdoc at the Pfizer Analytical Research Centre (PARC) with Prof. Pat Sandra on High Resolution Supercritical Fluid Chromatography (SFC) for Pharmaceutical Analysis.

During his years at Pfizer R&D UK in the Analytical R&D department Claudio worked on implementing new technologies within analytical development workflows, including hyphenated technologies and detectors, including 2D LC–MS, GC–MS, SFC–MS, HILIC, CE, cCAD, and more recently also computational predictive packages, such as QSRR, degradation predictors, solubility predictors, separation software packages, and automation. Claudio has recently accepted a role with Novartis R&D in the RadioLigand Therapy line taking onboard the analytical challenges of the peculiar pharmaceuticals.

In this video interview, Claudio discusses the following topics:

• Is supercritical fluid chromatography a mature or a niche technology in pharmaceutical development?

• Have there been any technological developments that have made SFC a more viable technology in practice?

• What types of analytes is SFC suitable for?

• What is the future of SFC?