This application note outlines a cryogen-free approach to collect and analyse ozone-depleting substances (ODS) and halogenated greenhouse gases (GHGs) in 100% humidity ambient air. The system uses automated canister sampling, a Nafion dryer for water vapour management, and GC-MS with selected ion monitoring to quantify 34 target compounds. The method achieves detection limits in the 0.08-0.30 ppt range, with good linearity, precision, and accuracy, meeting international requirements for monitoring these critical substances. The cryogen-free design and ability to handle highly humid samples make this a flexible and efficient solution for industrial ODS and GHG monitoring worldwide.
LC/MS Based Characterization Workflow of GLP-1 Therapeutic Peptide Liraglutide and Its Impurities
January 14th 2025This application note demonstrates a liquid chromatography/quadrupole time-of-flight mass spectrometer (LC/Q-TOF MS) workflow for the identification and characterization of therapeutic peptides.