LCGC E-Books

 

LCGC is pleased to present a series of educational e-books covering the latest innovations in chromatography. 

 

 

Advancing Chiral Separations

While scientists have known about the presence of chiral molecules for more than 150 years, the field of chiral chemistry is far from stagnant—especially in the world drug design and development. Given the serious problems that can occur if enantiomeric impurities are present in a drug, developers need to keep abreast of the newest techniques for fast and effective chiral separations. For these reasons, LCGC’s newest ebook, Advancing Chiral Separations, sponsored by Regis Technologies, is an important resource for anyone involved in drug discovery and early development.

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LC– and IC–MS Technologies and Workflows to Improve Pesticide Analysis

Higher demand for protection from pesticides in food is increasing pressure on pesticide residue laboratories, who handle high sample volumes and must provide results promptly and in compliance with strict quality control procedures. To help these laboratories keep up, this new e-book presents information that can help analysts improve their methods and workflows for pesticide residue testing.

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Methods for Characterizing Monoclonal Antibodies

Therapeutic monoclonal antibodies (mAbs) and their variants, such as bispecific mAbs and antibody–drug conjugates, are complex molecules that require careful characterization and quality control to ensure their safety and efficacy. This new e-book, presented jointly by LCGC and BioPharm International, provides essential information about the methods used for those purposes. 

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Guide to Sample Preparation

LCGC’s beloved “Guide to Sample Preparation” wallchart is now available in digital form! These easy-to-follow flow charts guide you from initial considerations through to the choice of approach, and then take you through the steps of supercritical fluid extraction, modern Soxhlet extraction, solid–liquid extraction, solid-phase extraction, classical liquid–liquid extraction, or QuEChERS.

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Advancing the Science of Medical Cannabis Analysis

The medical use of cannabis is increasing. As a result, there is a pressing need to establish and disseminate rigorous methods for the characterization and routine testing of cannabis. Fortunately, experienced analytical chemists are bringing their expertise to the field. In this new e-book, developed in collaboration with the Cannabis Science Conference, leading experts share their perspectives on the current state of cannabis analysis, explain their contributions to advance it, and outline what is still needed. 

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Beyond GPC: Using Light Scattering for Absolute Polymer Characterization

While conventional calibration for gel permeation (GPC) and size-exclusion chromatography (SEC) are useful for polymer characterization, there are inherent disadvantages in these analyses. Adding multi-angle light scattering (MALS) detection can help overcome the challenges faced with single-detector chromatography. For more complex polymers, asymmetric flow field-flow fractionation (AF4) offers additional capabilities.

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Current Trends in Food Analysis

In recent years, food analysis has blossomed out from a singular focus on food safety to a study of a wide array of questions such as the authentication of food origin and the nutritional aspects of natural food compounds. In this new e-book, we explore some current trends in food analysis and also provide some concrete advice for preparing food samples for analysis.

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Quantitation of Biopharmaceuticals & Pharmaceuticals by Mass Spectrometry

The quantitation of proteins in complex biological samples is an important and challenging task. Quantitation of small-molecules, while less challenging, also requires some special considerations. This new e-book presents essential information about these analyses, from general precepts through specific considerations when developing an LC–MS-MS method.

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Advancing the Analysis of Pesticides and Other Chemical Residues

The presence of pesticides and other chemical contaminants in food and dietary supplements is an important concern for both health and environmental reasons. In this new e-book, developed in collaboration with the organizers of the North American Chemical Residues Workshop (NACRW), four leading experts in the field, all frequent speakers at the conference, share some of their latest work and findings.

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The Ideal Chromatography Data System for a Regulated Laboratory

This e-book considers what functions and features should be available in an ideal chromatography data system (CDS) for use in a regulated analytical laboratory. Its four chapters consider the compliant analytical process, system architecture requirements, essential chromatographic functions for electronic ways of working, and ensuring regulatory compliance.

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Advancing GC Methods and Environmental Analysis

Gas chromatography (GC) is a powerful technique for environmental analysis. The articles in this new e-book look at both the technique and its application, providing essential information about GC fundamentals as well as an example of how the technique can be used in new ways in environmental analysis.

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Fundamental UHPLC Workflows for Biotherapeutic Characterization

The introduction of UHPLC revolutionized bio/pharma analytical laboratories and advances in technology promise more for the future. In this e-book, experts explain recent advances in UHPLC, and the basics of glycan analysis.

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Advancing Ion Chromatography with High Pressure

High pressures and columns with small particle sizes have been used in high-performance liquid chromatography (HPLC) for a long time, but not in ion chromatography (IC). But now, high pressures are coming to IC.

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Pesticide Residue Analysis: Tips and Tricks for the Whole Workflow

This e-book, based on a series of four web seminars, provides pesticide residue analysts with valuable information from Thermo Fisher Scientific about the development and optimization of methods and workflows for the analysis of pesticide residues in food.

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The Secrets to Successful Gradient Separations

Liquid chromatography separations using gradient elution have the potential to be faster, give better detection limits, and have more flexibility than separations using isocratic elution. However, problems can occur with gradients. Some of these problems are inherent to the technique but can be avoided or accommodated with a little care. Others result from a poor understanding of gradient elution. In this new e-book, John Dolan, renowned LC expert and the longtime author of the "LC Troubleshooting" column in LCGC, presents the secrets to achieving success with gradient separations.

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Advancing Biopharma Analysis with Light-Scattering Detection

To characterize biopharmaceuticals, particularly monoclonal antibodies and antibody–drug conjugates (ADCs), you need a complete toolbox of powerful tools. You are probably familiar with LC–MS methods. But have you seen what light-scattering detection can do?

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Metabolomics: Prospects and Pitfalls

Given the complexity of biological systems, studying the metabolome is a challenging undertaking. Prof. Oliver Fiehn, PhD, Director of the NIH West Coast Metabolomics Center, University of California, Davis, explains steps to follow in the metabolomic workflow and addresses common metabolomic questions.

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Applications of Ion Chromatography

You know the classic uses of ion chromatography (IC), like measuring inorganic ions in drinking water. But do you know what else it can do?

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Critical Choices in HPLC

In chromatography, the better your understanding of the fundamental mechanisms, the easier it will be for you to develop successful methods. This new e-book provides a guide to essential information in HPLC.

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Controlling Selectivity in Reversed-Phase LC

Reversed-phase liquid chromatography (LC) is the most common mode of liquid chromatography, and a powerful analytical tool. Getting the most from it, however, requires achieving the selectivity needed for your specific separation. In this new e-book, John Dolan, renowned LC expert and the longtime author of the "LC Troubleshooting" column in LCGC presents four steps to controlling selectivity in reversed-phase LC.

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Analytical Tools for Biopharmaceutical Characterization

In this new e-book, leading experts present the latest analytical tools for characterizing biopharmaceuticals, including chromatographic methods, mass spectrometry methods, and focused methods for analyzing carbohydrates on therapeutic glycoproteins.

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Advances in Water Analysis

This new e-book brings together vital information on water analysis methods, including:

  • Targeted analysis of pharmaceuticals and personal care products in water - An innovative approach to ionization in LC-MS to increase signal intensities
  • Advice on the suitability of various sample preparation approaches An alternative sample preservative to improve the analysis of bromate in drinking water
  • Views on LC and mass spectrometric methods
  • The impact of trace contaminants on biota and human health

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Advances in Ion Chromatography

This exclusive e-book assembles the top experts from the top IC Research and Development from across the world to provide state-of-the-art reviews surrounding elements of this well established separation technique.

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Advances in GC-MS Analysis of Pesticides

In this new e-book, authors from the US Department of Agriculture, academia, and a European Union Reference Laboratory discuss advances in the analysis of pesticide residues using gas chromatography–mass spectrometry (GC–MS) methods.

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Five Keys to Successful Gas Chromatography

John Hinshaw, renowned expert in gas chromatography and the longtime author of the “GC Connections” column in LCGC, provides invaluable advice about how to handle some of the most common difficulties faced by users of gas chromatography as well as with best practices to avoid problems in the first place. The five chapters in this new e-book will cover:

• Peak Problems: How to handle partially resolved or distorted peaks that yield poor quantitation

• System Operation: The steps to follow for restoring an idle GC column to operating condition

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Five Keys to Successful LC Methods

In this new e-book, John Dolan, renowned LC expert and the longtime author of the "LC Troubleshooting" column in LCGC, presents invaluable advice for how to handle the most common difficulties faced by users of liquid chromatography as well as best practices to avoid problems in the first place.

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Innovations in Environmental Analysis

No matter what type of environmental testing you do, you need the latest methods This new special issue brings together vital information on methods for environmental analysis.

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Innovations in Food Analysis

Whether you are conducting food safety testing, nutritional research, or product development, you need the latest methods. This new special issue is here to help, bringing together vital information on methods for food analysis, illustrated with examples.

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