Where Separation Science is Heading: Quotes

Celebrating 25 Years of LCGC Cover
Quotes from leading separation scientists on the future of separation science and the challenges that must be addressed.


Click here to view the slideshow.

Click here to view the full issue.

Featured LCGC Interviews

The Future of Chromatographic Method Development in Pharma

Analytical chemists are always seeking to make method development more efficient. For nearly two decades, Chris Welch led his teams at the Merck & Co. to constantly drive innovation in this area. Following his recent retirement from the company last year, he and his colleagues wrote a paper about the current state of method development for pharmaceutical research and where it is heading. He recently spoke to us about this topic.

Analyzing Artificial Sweeteners as Environmental Contaminants

The Column spoke to Núria Fontanals, a senior researcher at the Department of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Spain, discusses the role and application of HILIC–HRMS methods to analyse artificial sweeteners as emerging organic contaminants (EOCs).

Gas Chromatography

Injecting Water onto a GC Column: Solving the Mystery of Poor Chromatography

By Chris English

Ethylene glycol is a particularly difficult compound to analyze because it is not easily extracted from water. Many environmental samples originate from water runoff at airports, where ethylene glycol is used as a de‑icing agent for airplanes during winter months. Hydraulic fracturing is a technique where pressurized fluid and sand or other solids (proppant) are used in gas drilling to allow gas extraction. Glycols are a common ingredient in most hydraulic fracturing fluid and play a key role in preventing emulsifications and stabilizing the solutions. The direct aqueous injection of ethylene glycol is challenging because it can be difficult to attain reproducibility and good peak shape. The large expansion volume of water can cause backflash, carryover can cause inconsistent results, and excess water can extinguish the flame ionization detection (FID) flame. This article describes a robust approach to analyze glycols in aqueous samples, which reduces downtime and maintains sensitivity.

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Mass Spectrometry

Headspace Solid-Phase Microextraction Coupled with Gas Chromatography–Mass Spectrometry for the Characterization of Polymeric Materials

By Peter Kusch

HS-SPME-GC–MS is a valuable technique for identifying volatile organic compounds, additives, and degradation products in industrial rubber, car labeling reflection foil, and bone cement materials.

Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs

By Ira S. Lurie, Lauriane Tremeau-Cayel, Walter F. Rowe

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.

Sample Preparation

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Recent Advances in Solid-Phase Microextraction, Part I: New Tricks for an Old Dog

By Douglas E. Raynie

A look at recent advances in SPME, such as increasing the sorbent surface area available for extraction, accommodating direct analysis by mass spectrometry, and sorbent overcoating to resist fouling by sugars and lipids

Partner Organizations

Chinese American Chromatography Association (CACA)

About CACA



ChromAcademy Homepage


The LCGC Blog: Optimizing Sensitivity in Splitless Capillary GC with FID Detection

By Tony Taylor

It is often possible to achieve better sensitivity and lower limits of detection and quantitation using standard gas chromatography (GC) equipment—here I’m referring to a standard split/splitless injection port and a Flame Ionization Detector (FID). Paying attention to some of the fundamental variables as well as some of the more esoteric considerations can lead to much improved method performance.

The LCGC Blog: Forensic Drug Analysis: GC–MS versus LC–MS

By Kevin A. Schug

If given the need to determine drug A or its metabolite in blood, 99% of the time I would choose to start with liquid chromatography–mass spectrometry (LC–MS).

Celebrating 35 Years

Sponsored Videos

Latest News

Fast GC Solution to Quantify Volatile Amines in Pharmaceuticals

Researchers from Merck and Agilent Technologies have developed a simple and fast generic gas chromatography–flame ionization detection (GC–FID) method for the quantitation of volatile amines in pharmaceutical drugs and synthetic intermediates.

Investigating the Flavour Profiles of E-Cigarettes

Researchers from Gdansk University of Technology, Poland, have investigated the flavour profiles of e-cigarette refill solutions using GC–MS/MS.


High-Throughput, Automated Volatiles Analysis in Air, Polymers, Water and Soil, Using Direct MS

Europe Broadcast: Wednesday, 18 July, 2018 at 1 pm BST | 2 pm CEST 

US Broadcast: Wednesday, July 18, 2018 at 11 am EDT | 10 am CDT | 8 am PDT 

Enhanced Productivity for VOCs Analysis in Water and Soil by Purge & Traps GC-MS

Wednesday 25 July, 2018

11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST

More Upcoming and On Demand Webcasts>>

LCGC eBooks

Miniaturized Analytical Equipment Solves Key Challenges for Laboratories
Sometimes, great solutions for analytical laboratories come in small packages. This ebook highlights the important role that miniaturized instruments play in addressing challenges faced by laboratories.

Go to eBook Library



HPLC Mobile Phases – 10 bad habits to avoid

The 10 bad habits to avoid when producing HPLC mobile phases.

10 Ways to Break Your LC-MS

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

lorem ipsum