Where Separation Science is Heading: Quotes

Celebrating 25 Years of LCGC Cover
Quotes from leading separation scientists on the future of separation science and the challenges that must be addressed.


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Featured LCGC Interviews

The Future of Chromatographic Method Development in Pharma

Analytical chemists are always seeking to make method development more efficient. For nearly two decades, Chris Welch led his teams at the Merck & Co. to constantly drive innovation in this area. Following his recent retirement from the company last year, he and his colleagues wrote a paper about the current state of method development for pharmaceutical research and where it is heading. He recently spoke to us about this topic.

Analyzing Artificial Sweeteners as Environmental Contaminants

The Column spoke to Núria Fontanals, a senior researcher at the Department of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Spain, about the benefits and applications of HILIC–HRMS methods to analyse artificial sweeteners as emerging organic contaminants (EOCs).

Gas Chromatography

Optimizing Splitless GC Injections

By Linx Waclaski

Splitless injections are sometimes necessary for trace analyses, where the analyst hopes to recover 100% of the analytes that are injected. Unfortunately, splitless injections can be challenging and using an imperfect method can lead to loss of analytes and poor peak shapes. The choice of inlet liner can have an impact on the data and one must consider the effects of geometry, packing, deactivation, and volume on introduction of analytes into the system. Other important inlet parameters to consider include inlet temperature, splitless hold time, and initial oven temperature.

Pressure Tuning: Increasing the Flexibility of Comprehensive Two-Dimensional Gas Chromatography

By Mohammed Sharif Khan, Phillip John Marriott

Comprehensive two-dimensional gas chromatography (GC×GC) offers significant improvement for volatile chemical separation. Selecting suitable first (1D) and second dimension (2D) columns normally requires consideration of the chemical composition of a sample. Replacing one of these dimensions with a two-column ensemble (for example, 1D1 + 1D2 for the 1D column), provided with a pressure tuning makeup gas between them, varies the relative retentions of compounds before the modulation step according to the junction pressure. This makes it possible to alter the apparent polarity of the 1D ensemble, and this alters peak positions in the 2D GC×GC space. This article presents an account of studies that suggest this offers potential for improved operation for a GC×GC laboratory.

Mass Spectrometry

Headspace Solid-Phase Microextraction Coupled with Gas Chromatography–Mass Spectrometry for the Characterization of Polymeric Materials

By Peter Kusch

HS-SPME-GC–MS is a valuable technique for identifying volatile organic compounds, additives, and degradation products in industrial rubber, car labeling reflection foil, and bone cement materials.

Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs

By Ira S. Lurie, Lauriane Tremeau-Cayel, Walter F. Rowe

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.

Sample Preparation

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Recent Advances in Solid-Phase Microextraction, Part I: New Tricks for an Old Dog

By Douglas E. Raynie

A look at recent advances in SPME, such as increasing the sorbent surface area available for extraction, accommodating direct analysis by mass spectrometry, and sorbent overcoating to resist fouling by sugars and lipids

Partner Organizations

Chinese American Chromatography Association (CACA)

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The LCGC Blog: Improve Sensitivity and Reproducibility Using Pulsed Pressure Splitless GC Injection

By Tony Taylor

In my previous blog, I discussed the possibility of backflash in splitless GC injection and its effect on quantitative reproducibility and carry-over. While much is written in the literature on optimization of splitless injection conditions, little is available on the implementation and optimization of increased head pressure (pressure pulsed) injection, so we will concentrate on this aspect of injection optimization.

The LCGC Blog: How Should Gender Equity Be Addressed at Conferences?

By Kevin A. Schug

For an international conference, highlighting the diversity of research, and the people performing it, is important. Diversity comes in a lot of different flavors: Industrial vs. academic; different cultures, values, needs, and resources; age and gender; among others. Representatives from all different backgrounds and experiences should be given a voice.

Celebrating 35 Years

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EAS 2018: Analytical Solutions to the World's Problems

The theme of the 2018 Eastern Analytical Symposium and Exposition is “Analytical Solutions to the World’s Problems.” The EAS has always been about problem solving. This year, we focus on problems that affect the world.

Shimadzu Receive NRW.Invest Award

Shimadzu has been awarded the 2018 NRW.Invest Award by the North Rhine‑Westphalia (NRW) region of Germany.


Natural Product Purification by Centrifugal Partition Chromatography (CPC)

Monday, 15 October 2018

11 am EDT | 8 am PDT | 1600 BST | 1700 CEST

CESI-MSMS: Quantitation of Highly Polar Pesticides Beyond the Limitations of LC-MSMS

Wednesday, Oct. 17, 2018

2pm EDT | 1pm CDT | 11am PDT | 3pm BST | 4pm CEST

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LCGC eBooks

Miniaturized Analytical Equipment Solves Key Challenges for Laboratories
Sometimes, great solutions for analytical laboratories come in small packages. This ebook highlights the important role that miniaturized instruments play in addressing challenges faced by laboratories.

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HPLC Mobile Phases – 10 bad habits to avoid

The 10 bad habits to avoid when producing HPLC mobile phases.

10 Ways to Break Your LC-MS

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

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