Slideshow

Where Separation Science is Heading: Quotes

Celebrating 25 Years of LCGC Cover
Quotes from leading separation scientists on the future of separation science and the challenges that must be addressed.

 

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Featured LCGC Interviews

The Future of Chromatographic Method Development in Pharma

Analytical chemists are always seeking to make method development more efficient. For nearly two decades, Chris Welch led his teams at the Merck & Co. to constantly drive innovation in this area. Following his recent retirement from the company last year, he and his colleagues wrote a paper about the current state of method development for pharmaceutical research and where it is heading. He recently spoke to us about this topic.

Analyzing Artificial Sweeteners as Environmental Contaminants

The Column spoke to Núria Fontanals, a senior researcher at the Department of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Spain, about the benefits and applications of HILIC–HRMS methods to analyse artificial sweeteners as emerging organic contaminants (EOCs).

Gas Chromatography

Optimizing Splitless GC Injections

By Linx Waclaski

Splitless injections are sometimes necessary for trace analyses, where the analyst hopes to recover 100% of the analytes that are injected. Unfortunately, splitless injections can be challenging and using an imperfect method can lead to loss of analytes and poor peak shapes. The choice of inlet liner can have an impact on the data and one must consider the effects of geometry, packing, deactivation, and volume on introduction of analytes into the system. Other important inlet parameters to consider include inlet temperature, splitless hold time, and initial oven temperature.

Pressure Tuning: Increasing the Flexibility of Comprehensive Two-Dimensional Gas Chromatography

By Mohammed Sharif Khan, Phillip John Marriott

Comprehensive two-dimensional gas chromatography (GC×GC) offers significant improvement for volatile chemical separation. Selecting suitable first (1D) and second dimension (2D) columns normally requires consideration of the chemical composition of a sample. Replacing one of these dimensions with a two-column ensemble (for example, 1D1 + 1D2 for the 1D column), provided with a pressure tuning makeup gas between them, varies the relative retentions of compounds before the modulation step according to the junction pressure. This makes it possible to alter the apparent polarity of the 1D ensemble, and this alters peak positions in the 2D GC×GC space. This article presents an account of studies that suggest this offers potential for improved operation for a GC×GC laboratory.

Mass Spectrometry

Headspace Solid-Phase Microextraction Coupled with Gas Chromatography–Mass Spectrometry for the Characterization of Polymeric Materials

By Peter Kusch

HS-SPME-GC–MS is a valuable technique for identifying volatile organic compounds, additives, and degradation products in industrial rubber, car labeling reflection foil, and bone cement materials.

Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs

By Ira S. Lurie, Lauriane Tremeau-Cayel, Walter F. Rowe

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.

Sample Preparation

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Recent Advances in Solid-Phase Microextraction, Part I: New Tricks for an Old Dog

By Douglas E. Raynie

A look at recent advances in SPME, such as increasing the sorbent surface area available for extraction, accommodating direct analysis by mass spectrometry, and sorbent overcoating to resist fouling by sugars and lipids

Partner Organizations

Chinese American Chromatography Association (CACA)

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ChromAcademy

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LCGC Blog

The LCGC Blog: Solve Carryover Problems in Gas Chromatography

By Tony Taylor

Let’s first properly define carry-over in the context that I’d like to discuss here. An injection is made and a chromatogram obtained. On injecting a “blank” as the next injection, one or more of the components of the previous injection appear in the “blank” chromatogram.

The LCGC Blog: Analytical Chemistry is Central to All Modern Research

By Kevin A. Schug

I just finished a 10-month stint as Interim Associate Dean for Research and Development in the College of Science at The University of Texas Arlington. I was afforded that opportunity when some restructuring in another college left a temporary vacancy, which I was asked to fill. I certainly considered it an honor to be asked to serve in that role, but the temporary nature of that role also piqued my interest. For me, it seemed like a chance to do an internship in administration, to see if I liked it or not. I worked with great people, I did not really like the role.

Celebrating 35 Years

Sponsored Videos

Latest News

Retroactive Toxicology Study on Adolescents Using GC–MS

Toxicological surveillance of illicit prescription and illegal drug abuse has been carried out using post-mortem data from Clark Country, Nevada, USA, with GC–MS, headspace GC–MS, GC×GC–MS, LC–MS, and ELISA.

Waters and Restek Announce Co-Marketing Agreement

Waters and Restek have entered into a co-marketing agreement aimed at food safety laboratories and promoting the use of Waters gas chromatography–mass spectrometry instruments with Restek GC consumables.

LCGC eBooks

Miniaturized Analytical Equipment Solves Key Challenges for Laboratories
Sometimes, great solutions for analytical laboratories come in small packages. This ebook highlights the important role that miniaturized instruments play in addressing challenges faced by laboratories.

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CHROMacademy

HPLC Mobile Phases – 10 bad habits to avoid

The 10 bad habits to avoid when producing HPLC mobile phases.

10 Ways to Break Your LC-MS

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

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