Liquid Chromatography

The 2014 Emerging Leader in Chromatography: Andre de Villiers

By LCGC Editors

LCGC recently spoke with the 2014 LCGC Emerging Leader in Chromatography award winner, Andre de Villiers, an Associate Professor of Science at Stellenbosch University in South Africa, about his current research analyzing natural products, his various interests and collaborations in analytical chemistry, and his role as a teacher.

Liquid Chromatography Methods for the Separation of Short RNA Oligonucleotides

By Bing Mao, Mirlinda Biba, Joe P. Foley, Christopher J. Welch

A review of LC methods and strategies for the chromatographic separation of short RNA oligonucleotides

Gas Chromatography

Critical Evaluation of GC Methods

By LCGC Editors

How to spot weaknesses in methods before problems occur

Critical Evaluation of GC Methods

By Tony Taylor

How to spot weaknesses in methods before problems occur

Electronic Control of Carrier Gas Pressure, Flow, and Velocity

By John V. Hinshaw

How does a GC system set and control gas pressures, flows, and carrier gas velocities electronically?

Mass Spectrometry

Large-Scale Targeted Protein Quantification Using Wide Selected-Ion Monitoring Data-Independent Acquisition

By Andreas F.R. Hühmer, Sonia Ting, Reiko Kiyonami, Vlad Zabrouskov, Michael Senko, Jarrett Egertson, Michael MacCoss

This article describes the development of a new data-independent acquisition (DIA) workflow for protein quantification that uses a mass spectrometer that combines three types of mass analyzers to achieve lower limits of detection (LOD), higher sensitivity, more accurate quantitative results, wider dynamic range, and better reproducibility than existing high-resolution accurate-mass (HRAM) tandem mass spectrometry (MS-MS) DIA workflows.

GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic Compounds

By Hang P. Nguyen, Irene W. Kimaru

In most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.

Application of Ambient Sampling Portable Mass Spectrometry Toward On-Site Screening of Clandestine Drug Operations

By Seth E. Hall, Christopher C. Mulligan

Worldwide trends in illicit drug use and production have shifted toward an increase in synthetic analogues and the emergence of new variations in their manufacture.

Sample Preparation Techniques

Developments in Green Chromatography

By Jacek Namiesnik, Marek Tobiszewski

Green analytical chemistry is a widely recognized concept that has led to the development of new analytical methods with reduced environmental impact and minimized analyst occupational exposure. This article presents the most recent progress in the development of greener sample preparation and chromatographic separation techniques.

Exploring the Possibilities of High-Throughput Sample Preparation

By Douglas E. Raynie

In sample preparation, what does "high-throughput" really mean?

Automating Analysis of Pain Management Drugs in Urine

By Fredrick D. Foster, Bill Brewer

This article discusses the benef ts of using automated dispersive solid-phase extraction (dSPE) rather than standard SPE in urine analysis.

Partner Organizations

 

Sepu, China's Largest Chromatography Training Site

About Sepu

News from Sepu

 

Chinese American Chromatography Association (CACA)

About CACA

 

ChromAcademy

ChromAcademy Homepage

LCGC Blog

The LCGC Blog: Chromatography Technical Tips - Sweating the Small Stuff

By Tony Taylor

In this issue – I hope to outline some 'small bolts' that are commonly ignored in everyday chromatography and mass spectrometry - instrument settings that I have to come call 'lock and leave' parameters. We can generate data without changing them or paying them any attention, but how much better could our data be if we bothered to optimise them.

The LCGC Blog: Responsible Unconventional Oil and Gas Exploration in Colombia

By Kevin A. Schug

A program was formulated to help educate public opinion leaders on the fundamentals of unconventional natural gas and oil extraction, to convey the current state of research on the topic, and to disseminate and discuss prospective regulations that have been formulated over the past two to three years.

Latest News

Metabolic Profiling of Tea

A new study published in the Journal of Chromatography A presents metabolite profiling of tea (Camella sinensis) harvested from the Bulang Mountains in Yunnan, China, using multidimensional gas chromatography–mass spectrometry (GC×GC–MS) to determine the impact of seasonal changes.

Detecting Nerve Agent Exposure

Scientists at the Norwegian Defence Research Establishment (Kjeller, Norway) are working in collaboration with the University of Oslo (Oslo, Norway) to develop new methods to detect the illicit use of nerve agents. In a recent study published in the journal Analytical Chemistry, the team presented a novel method for the quantification of nerve agent metabolites in human serum and urine by combining salting-out assisted liquid–liquid extraction (SALLE) and on-line solid-phase extraction–liquid chromatography–tandem mass spectrometry (SPE–LC–MS–MS).

Speeding Up Drug Metabolism Screening

A new study published in the journal Analytical Chemistry presents a drug metabolism strategy based on microsome mesoporous organosilica nanoreactors coupled with high performance liquid chromatography–mass spectrometry (HPLC–MS) to screen for potential drug toxicity.

CHROMacademy Training Debuts in Africa

The 3rd African Liquid Chromatography Workshop was held on 6–10 October 2014 in Nairobi, Kenya, at the ChromAfrica Training Centre.

Douglas E. Raynie Joins LCGC Editorial Board

LCGC Magazine is pleased to announce the addition of Douglas E. Raynie to its editorial advisory board.

Webcasts

Streamline Data Analysis of Tandem Mass Spectrometry for Inborn Errors of Metabolism Research

Wednesday December 10 2014 —8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET

Fast and Accurate Analysis of Beer and Wort Samples Using Automated Discrete Analysis

Thursday December 11 2014 —8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET

More Upcoming & On Demand Webcasts>

LCGC eBooks

Featured: Analytical Tools for Biopharmaceutical Characterization: 

In this new e-book, leading experts present the latest analytical tools for characterizing biopharmaceuticals, including chromatographic methods, mass spectrometry methods, and focused methods for analyzing carbohydrates on therapeutic glycoproteins.

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