Featured LCGC Interviews

Back to Nature with Flash Chromatography

Dr Vera Thoss from Bangor University (Bangor, Wales) spoke to Bethany Degg of The Column about her work investigating the chemistry of plants and the value of flash chromatography in this area of research.

Liquid Chromatography

Food Allergen Analysis Using LC–MS–MS

By Ashley Sage

Changes to the European Food Safety Authority (EFSA) regulations on food labelling, and the strengths and limitations of new and existing methods for the detection of allergens in food are discussed in this article.

Fast and Simple Determination of Free Amino Acids in Beer

By Gesa J. Schad and Brigitte Bollig

A rapid and reliable high performance liquid chromatography–mass spectrometry (HPLC–MS) method to determine amino acids in beer is presented.

New Chromatography Columns and Accessories for 2015

By M. Swartz

This is our annual review of new liquid chromatography (LC) columns and accessories introduced at Pittcon and throughout the previous year.

Gas Chromatography

Understanding Electron Ionization Processes for GC–MS

By LCGC Editors

Many of us use electron ionization (EI) in gas chromatography–mass spectrometry (GC–MS) without a good understanding of the technique and how we might manipulate the process to give more appropriate results or a better understanding of the analytes under investigation.

Extending the Compatible Analyte Volatility Range for Indoor Air Quality and Material Emissions Testing Using Multi-Bed Thermal Desorption Tubes

By Caroline Widdowson, David Barden

This article describes sampling methodology for thermal desorption–gas chromatography (TD–GC) that can extend the compatible analyte range of tests used to determine chemicals released from materials, as well as associated indoor air quality measurements.

GC Troubleshooting in Petrochemical Analysis

By Stephen Harrison

A guide to simple troubleshooting steps in gas chromatography (GC) with an emphasis on petrochemical analysis.

Mass Spectrometry

Quantifying Small Molecules by Mass Spectrometry

By P. Jane Gale, Alfred L. Yergey, Mark W. Duncan, Kate Yu

The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration. There are, however, some special considerations that are necessary when a mass spectrometer is used as a quantitative tool.

Unraveling the Links Between Diet and Human Health Using LC–MS-MS

By LCGC Editors

We recently spoke to Gary Duncan and Wendy Russell of the Rowett Institute of Nutrition & Health in Aberdeen, Scotland, about the significance of phytochemical bioavailability to human health and the important role of liquid chromatography linked to tandem mass spectrometry (LC–MS-MS) in their research.

GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic Compounds

By Irene W. Kimaru, Hang P. Nguyen

In most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.

Sample Preparation Techniques

Simplifying Liquid Extractions

By Erica Pike

The benefits of supported liquid extraction (SLE) in sample cleanup and, in particular, the use of a synthetic SLE sorbent are discussed.

Pyrolysis for the Preparation of Macromolecules and Analysis by Gas Chromatography

By Douglas E. Raynie

When pyrolyzed, macromolecules will decompose into smaller fragments that can have the appropriate volatility for gas chromatography (GC) separation and analysis.

Understanding and Improving Solid-Phase Extraction

By Dawn Wallace Watson, Douglas E. Raynie

In this installment of "Sample Prep Perspectives," we cover some of the basic scientific principles behind solid-phase extraction (SPE) to allow the correct mode of extraction to be selected through an understanding of how analytes interact with and are separated by the sorbent.

Partner Organizations


Sepu, China's Largest Chromatography Training Site

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News from Sepu


Chinese American Chromatography Association (CACA)

About CACA



ChromAcademy Homepage


The LCGC Blog: Four Steps to Troubleshooting an HPLC Problem

By Tony Taylor

What if we could make the troubleshooting poster on the laboratory wall come to life? What if we could build an engine which figured out the most likely causes of groups of symptoms and offer these up as a prioritised list for folks to work through and give them supporting information on each problem, why it occurred, how to fix it and, crucially, how to avoid it happening next time?

A New Consortium of Researchers for Environmental Analysis and Remediation

By Kevin A. Schug

CLEAR is an endeavor to create a consortium of experts interested in building and propagating activities related to the assessment of the potential impact of industrial activities on the environment, as well as the creation of new solutions to mitigate problems associated with these activities.

Latest News

Agilent Technologies and Scion Announce GC Instrument Control Agreement

Agilent Technologies (California, USA) and Scion Instruments (California, USA) have announced a gas chromatography instrument agreement, which will allow users to operate instruments from both manufacturers in each company’s chromatography data systems.

Sustainable Reuse of Fracking Water

Researchers from the University of Colorado have characterized flow-back water generated from fracking activities, using a combination of analytical techniques, to determine how best to treat wastewater so that it can be recycled.

Using Proteomics to Determine Key to Embryo Implantation Success

A new study presents a proteomics approach to investigate changes at the molecular scale that could control whether or not embyro implantation using IVF is successful.

Dietary Supplements Tainted with Amphetamine Isomer BMPEA

Selected dietary supplements labelled to contain Acacia rigidula have been found to be adulterated with the amphetamine isomer ?-methylphenylethylamine (BMPEA).

GC–MS Detects Chemical Cue for Mosquitoes in Soil

Cedrol, a sequisterpene alcohol found in the essential oil of connifers, could be a potent chemical cue for pregnant mosquitoes seeking the ideal location to lay their eggs.


Achieve More With The Right Chromatography Data System

Thursday, April 30, 2015 — 9:00 am EDT/ 2:00 pm BST/ 3:00 pm CEST


HRMS in Clinical Research: From Targeted Quantification to Metabolomics

Thursday, May 7, 2015 — 8:00 am PDT/ 11:00 am EDT/ 4:00 pm BST/ 5:00 pm CET


Editors’ Series: Rapid Pesticides Analysis Using Low-Pressure Gas Chromatography with Tandem Mass Spectrometry

Wednesday, May 13, 2015 — 8:00am PDT/ 11:00am EDT/ 4:00pm BST/ 5:00pm CEST

Pesticide Residue Analysis: Tips and Tricks for the Whole Workflow

PART III: Wednesday, June 17, 2015 — Maximizing Analysis Efficiency through New GC-MS Approaches — 8:00am PDT/ 11:00am EDT/ 4:00pm BST/ 5:00pm CEST

Tuesday, June 23, 2015 — 8:00am/ PDT/ 10:00am CDT/ 11:00am EDT


More Upcoming & On Demand Webcasts>>

LCGC eBooks

Metabolomics: Prospects and Pitfalls

Given the complexity of biological systems, studying the metabolome is a challenging undertaking. Prof. Oliver Fiehn, PhD, Director of the NIH West Coast Metabolomics Center, University of California, Davis, explains steps to follow in the metabolomic workflow and addresses common metabolomic questions

Go to E-Book Library>>



Reversed-Phase HPLC for the Analysis of Biomolecules

The following article from LCGC's ChromAcademy introduces the fundamentals of biopharmaceutical analysis and cover the use of reversed-phase HPLC in the analysis of biomolecules.

HPLC Troubleshooting Guide to Cycling Baselines and Pressure Fluctuations

HPLC troubleshooting guide to cycling baselines and pressure fluctuations from LCGC's ChromAcademy.

My LC–MS isn’t behaving! Where do I start?

Instrument manufacturers try to convince us that mass spec is just another detector. Most of us who work with LC-MS know that’s simply not the case – they can be maintenance intensive, unforgiving and generate complex information. When they’re not working it can be difficult to work out exactly where the problem lies. Here’s some advice to point you in the right direction

HPLC Column Dead Volume

A question about column dead volume. If the hold-up volume (time) is the extra-column dead volume expressed in time or volume. What is the column dead volume and how can it be calculated?

Seven Must Know Points to Understand Atmospheric Pressure Chemical Ionization

CHROMacademy delivers key knowledge quickly in bite-size modules, and to prove this here is our seven point guide to understanding atmospheric pressure chemical ionization.