Fundamental Questions

As you hurry through your daily work in the analytical laboratory, are you failing to ask yourself some fundamental questions about the methods you use and the results you produce?

This collection of short articles from LCGC’s digital magazine, The Column, raises four key questions you should ask. And if the answers aren’t what you hoped, we offer advice for addressing the gaps.

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Featured LCGC Interviews

The Challenge of Accurate Protein Bioanalysis

Rainer Bischoff of the University of Groningen in the Netherlands has been studying the challenges involved in measuring protein-based pharmaceuticals (biopharmaceuticals) and exploring approaches to overcome it. He recently spoke to us about this work.

Detecting Carcinogens in Drinking Water

Water contamination has come to the forefront of global debate as a result of high profile cases such as those in Flint, Michigan, USA, or the pollution of the Ganges River in India. Koji Kosaka of the National Institute of Public Health, Japan, has investigated the contamination of the Yodo River Basin in Japan, with the precursors of the carcinogen N-Nitrosodimethylamine (NDMA). He recently spoke to LCGC about his use of high performance liquid chromatography (HPLC) to uncover the source of contamination and the chemical precursors responsible.

Liquid Chromatography

Making Method Development Faster for the Analysis of Natural and Artificial Flavourings

By Philipp Jochems, Gesa Schad

A simple, rapid, and robust ultrahigh-performance liquid chromatography (UHPLC) method has been developed for the simultaneous determination of natural and artificial vanilla flavouring substances as well as some precursors has been developed using an automated method scouting or method optimization workflow.

How to Tackle an Unknown: Notes from the Fourth Method Development Olympics at CoSMoS

By Michael P. Balogh

How would you analyze a bag of gummy bears that showed up on your laboratory bench? This was the challenge taken on by teams of analysts in advance of the Conference on Small Molecule Science (CoSMoS) that was held in August 2015 in San Diego, California. This article shares insights from how the finalists approached the question.

Gas Chromatography

Coupling Gas Chromatography with Ion Mobility Spectrometry

By Zygfryd Witkiewicz, Urszula Perycz, Mirosław Maziejuk, Jarosław Puton

Chromatography connected with ion mobility spectrometry (IMS) is not commonly used, but is being investigated more. IMS is an independent analytical technique with very good detectability and a rather small separation ability. One favourable property of IMS is that it can work with ambient pressure and can be easily connected to a gas chromatograph. Analytical applications of GC–MS are very different and encompass investigations into food, medical science, environment, drugs of abuse, chemical warfare agents, and explosives.

New Gas Chromatography Products for 2016

By John V. Hinshaw

The number and type of new product introductions this year are an indication of the continuing viability of gas chromatography.

Mass Spectrometry

Desorption and Ionization Mass Spectrometry in Research Laboratories

By Giuseppe Astarita, Bindesh Shrestha

The three key applications for desorption and ionization techniques are rapid, in situ screening; direct analysis of extracted samples or planar chromatography spots; and scanning samples along x and y axes.

Extending the Hydrocarbon Range for the Analysis of Soil Gas Samples Using Automated Thermal Desorption Coupled with Gas Chromatography–Mass Spectrometry

By Lee Marotta, Stephen Varisco, Miles Snow, Tom Kwoka, Robert Thomas

When monitoring toxic gases emitted from the soil, it is often necessary to recover compounds with a boiling point above that of napthalene. The use of thermal desorption makes that possible.

Sample Preparation

New Sample Preparation Products and Accessories for 2016

By Douglas E. Raynie

Many of this year’s new products fit into recently identified trends, but one major driver of advances was not in our forecasts.

Trends in Sample Preparation

By Douglas E. Raynie

A comparison of the results from a new survey on sample preparation techniques to those of previous surveys, from 1991 to 2013, reveals some interesting trends.

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The Value of Chemometrics and Experimental Design to Analytical Chemists

By Kevin A. Schug

I believe that most analytical chemists do not appreciate what the world of chemometrics and experimental design statistics can add to their work.

The LCGC Blog: Investigating (and Solving) Robustness Issues in HPLC

By Tony Taylor

Not every method is as we would hope it would be. Some methods come to us in imperfect form and we have to live with them, while others are difficult separations and, by necessity, need to be developed using close control of several variables such as eluent pH, eluotropic strength, ionic strength, and so on.


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LCGC Slideshows

Slideshow: Seven Common Faux Pas in Modern HPLC

Seven outdated traditional practices that should not be performed without considering alternative approaches that can improve results, provide lower operation costs, or give faster run times. Instead of working harder, analytical scientists should work smarter. Learn more by clicking through the slideshow.

Slideshow: The Top 10 HPLC and UHPLC Column Myths

Webster’s New Collegiate Dictionary defines a myth as “an ill-founded belief held uncritically, especially by an interested group.” Could that group be misinformed chromatographers?

Latest News

Emily Hider and Derek Stevenson Awarded Jubilee Medal at HPLC 2016

Emily Hilder and Derek Stevenson were awarded the Jubilee Medal by the Chromatographic Society at HPLC 2016 in San Francisco, California, USA.

Martin Medal Awarded to Peter Myers and Iain Wilson at HPLC 2016

The Chromatographic Society (ChromSoc) awarded Professor Peter Myers and Professor Iain Wilson the Martin Medal at HPLC 2016 in San Francisco, California, USA.


LCGC E-Books

Advancing GC Methods and Environmental Analysis

Gas chromatography (GC) is a powerful technique for environmental analysis. The articles in this new e-book look at both the technique and its application, providing essential information about GC fundamentals as well as an example of how the technique can be used in new ways in environmental analysis.

Go to E-Book Library>>



GC Column Conditioning

In this article, technical expert Dr. Dawn Watson will cover the polarity of the stationary phase, the column length, internal diameter, thickness of the stationary phase film and the required upper operating temperature.

How to Optimize Key Variables in GC Analysis: Sample Introduction

An excerpt from LCGC’s e-learning tutorial on GC analysis at

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