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LCGC TV Video: Richard Henry on Narrow Particle Size Distribution in HPLC Columns: Fully porous particle columns with narrow particle distribution can improve the efficiency of HPLC separations. In this new video from LCGC TV, Richard Henry, a consultant from State College (Pennsylvania, USA) discusses the advantages of narrow particle distribution and whether optimized LC instruments are required for optimum performance.

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LCGC COLUMNISTS 2014

Sample Prep Perspectives | Ronald E. Majors: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments.
LATEST: UV Detector Problems


Perspectives in Modern HPLC | Michael W. Dong: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Superficially Porous Particles: Perspectives, Practices, and Trends


MS — The Practical Art | Kate Yu: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting | John Dolan: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: Problems with Large-Molecule Separations


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Features
Gas Cylinder Setup and Use
Safe and effective gas cylinder setup and use requires the right pressure regulators, fittings, tubing, and filters as well as careful attention to procedure. This month's instalment reviews how to get the best results from laboratory gas cylinders, how pressure regulators work, and what filters should be installed in gas lines.
Why You Need to Listen to Your Instrument?
We all have always been told that we need to listen, and to listen more carefully. Growing up, we were told to listen to our parents and our teachers. But have you considered listening to your analytical instruments?
Superficially Porous Particles: Perspectives, Practices, and Trends
An updated overview of the development of SPP technology, including benefits, limitations, and the theory behind its success
Ultra-Fast Analysis of Alkaloids and Permitted Additives in Dark Chocolate Products
A simple, rapid, and robust UHPLC method for the simultaneous determination of polyphenols, methylxanthines, sweeteners, and flavouring substances as well as some common preservatives has been developed using an automated method scouting and method optimization workflow.
Highlights of HPLC 2014
This year's symposium was held in New Orleans, Louisiana, USA. In this review, Ron Majors covers HPLC and UHPLC column and sample preparation highlights, summarizes the awards presented, and reviews the overall liquid-phase chromatographic trends.

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