Liquid Chromatography

The 2014 Emerging Leader in Chromatography: Andre de Villiers

By LCGC Editors

LCGC recently spoke with the 2014 LCGC Emerging Leader in Chromatography award winner, Andre de Villiers, an Associate Professor of Science at Stellenbosch University in South Africa, about his current research analyzing natural products, his various interests and collaborations in analytical chemistry, and his role as a teacher.

Liquid Chromatography Methods for the Separation of Short RNA Oligonucleotides

By Bing Mao, Mirlinda Biba, Joe P. Foley, Christopher J. Welch

A review of LC methods and strategies for the chromatographic separation of short RNA oligonucleotides

Gas Chromatography

Critical Evaluation of GC Methods

By LCGC Editors

How to spot weaknesses in methods before problems occur

Critical Evaluation of GC Methods

By Tony Taylor

How to spot weaknesses in methods before problems occur

Electronic Control of Carrier Gas Pressure, Flow, and Velocity

By John V. Hinshaw

How does a GC system set and control gas pressures, flows, and carrier gas velocities electronically?

Mass Spectrometry

Large-Scale Targeted Protein Quantification Using Wide Selected-Ion Monitoring Data-Independent Acquisition

By Andreas F.R. Hühmer, Sonia Ting, Reiko Kiyonami, Vlad Zabrouskov, Michael Senko, Jarrett Egertson, Michael MacCoss

This article describes the development of a new data-independent acquisition (DIA) workflow for protein quantification that uses a mass spectrometer that combines three types of mass analyzers to achieve lower limits of detection (LOD), higher sensitivity, more accurate quantitative results, wider dynamic range, and better reproducibility than existing high-resolution accurate-mass (HRAM) tandem mass spectrometry (MS-MS) DIA workflows.

GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic Compounds

By Hang P. Nguyen, Irene W. Kimaru

In most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.

Application of Ambient Sampling Portable Mass Spectrometry Toward On-Site Screening of Clandestine Drug Operations

By Seth E. Hall, Christopher C. Mulligan

Worldwide trends in illicit drug use and production have shifted toward an increase in synthetic analogues and the emergence of new variations in their manufacture.

Sample Preparation Techniques

Developments in Green Chromatography

By Jacek Namiesnik, Marek Tobiszewski

Green analytical chemistry is a widely recognized concept that has led to the development of new analytical methods with reduced environmental impact and minimized analyst occupational exposure. This article presents the most recent progress in the development of greener sample preparation and chromatographic separation techniques.

Exploring the Possibilities of High-Throughput Sample Preparation

By Douglas E. Raynie

In sample preparation, what does "high-throughput" really mean?

Automating Analysis of Pain Management Drugs in Urine

By Fredrick D. Foster, Bill Brewer

This article discusses the benef ts of using automated dispersive solid-phase extraction (dSPE) rather than standard SPE in urine analysis.

Partner Organizations


Sepu, China's Largest Chromatography Training Site

About Sepu

News from Sepu


Chinese American Chromatography Association (CACA)

About CACA



ChromAcademy Homepage


The LCGC Blog: Responsible Unconventional Oil and Gas Exploration in Colombia

By Kevin A. Schug

A program was formulated to help educate public opinion leaders on the fundamentals of unconventional natural gas and oil extraction, to convey the current state of research on the topic, and to disseminate and discuss prospective regulations that have been formulated over the past two to three years.

The LCGC Blog: Are we scared to properly explore selectivity options in HPLC?

By Tony Taylor

Much has been written about options for increasing efficiency in HPLC ? primarily through the use of core shell and sub 2 ?m particles, which have been used to increase efficiency, speed up separations or increase peak capacity. However, many separations can only be effectively improved, by optimising selectivity ? resolution is a function of selectivity, efficiency and retention, with selectivity being the most effective at achieving good resolution.

Latest News

Detecting Nerve Agent Exposure

Scientists at the Norwegian Defence Research Establishment (Kjeller, Norway) are working in collaboration with the University of Oslo (Oslo, Norway) to develop new methods to detect the illicit use of nerve agents. In a recent study published in the journal Analytical Chemistry, the team presented a novel method for the quantification of nerve agent metabolites in human serum and urine by combining salting-out assisted liquid–liquid extraction (SALLE) and on-line solid-phase extraction–liquid chromatography–tandem mass spectrometry (SPE–LC–MS–MS).

Douglas E. Raynie Joins LCGC Editorial Board

LCGC Magazine is pleased to announce the addition of Douglas E. Raynie to its editorial advisory board.

Pittcon 2015 Announces Award Recipients for Outstanding Achievements in Analytical Chemistry and Applied Spectroscopy

Pittcon 2015 has announced the recipients of 14 prestigious awards honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy.

Monitoring Plastic Exposure in Seabirds

Researchers from CSIRO Oceans and Atmosphere Flagship in Hobart, Australia, have published a new approach to monitoring plastic exposure in live birds. Featured in the journal Methods in Ecology and Evolution, the study describes the sampling of preen oil collected from seabirds using a simple swabbing method for gas chromatography coupled to mass spectrometry (GC–MS) analysis.1

Profiling Alzheimer's Disease Biomarkers in Blood Serum

In a new study published in the journal Electrophoresis, a metabolomics approach based on ultrafiltration followed by capillary electrophoresis coupled with mass spectrometry (CE–ESI–MS) is presented for the fingerprinting of polar metabolites in blood serum.


Streamline Data Analysis of Tandem Mass Spectrometry for Inborn Errors of Metabolism Research

Wednesday December 10 2014 —8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET

Fast and Accurate Analysis of Beer and Wort Samples Using Automated Discrete Analysis

Thursday December 11 2014 —8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET

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LCGC eBooks

Featured: Analytical Tools for Biopharmaceutical Characterization: 

In this new e-book, leading experts present the latest analytical tools for characterizing biopharmaceuticals, including chromatographic methods, mass spectrometry methods, and focused methods for analyzing carbohydrates on therapeutic glycoproteins.