Jobs in Analytical Chemistry

You may have an excellent educational background, and perhaps some very good experience, too. But are you prepared to get—and keep—your next job in analytical chemistry? This collection of short articles from LCGC’s digital magazine, The Column, offers essential advice for separation scientists who aspire to get a new job and succeed once there.

Read more.

Featured LCGC Interviews

Investigating Baby Food Using HILIC–MS/MS

Babies and infants experience rapid growth within a short timeframe and the nutrition that they absorb is therefore of the utmost importance. María Mateos-Vivas from the Department of Analytical Chemistry, Nutrition, and Food Science at the University of Salamanca, Spain, has used hydrophilic interaction liquid chromatography (HILIC) coupled to tandem mass spectrometry (MS/MS) to investigate the role of nucleotides on infant health. She recently spoke to us about this research.

Innovating Microfluidic Technologies

The future of biological and clinical research will depend on technological innovations and cross discipline co-operation as science seeks a deeper understanding of increasingly complex biological systems. The 2016 recipient of the AES Mid-Career Award, Amy Herr, and her team at the University of California Berkeley have explored these areas using a combination of chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, material science, and analytical chemistry to innovate new microfluidic analytical technology. She recently spoke to LCGC about this work.

Gas Chromatography

Sealing it with Septa

By John V. Hinshaw

Choosing the wrong septa can compromise method accuracy.

Coupling Gas Chromatography with Ion Mobility Spectrometry

By Zygfryd Witkiewicz, Urszula Perycz, Mirosław Maziejuk, Jarosław Puton

Chromatography connected with ion mobility spectrometry (IMS) is not commonly used, but is being investigated more. IMS is an independent analytical technique with very good detectability and a rather small separation ability. One favourable property of IMS is that it can work with ambient pressure and can be easily connected to a gas chromatograph. Analytical applications of GC–MS are very different and encompass investigations into food, medical science, environment, drugs of abuse, chemical warfare agents, and explosives.

Mass Spectrometry

Urine Analysis: The Good, the Bad, and the Ugly

By Jenny Cybulski

In clinical and forensic/toxicology laboratories, urine is a preferred matrix from which to quantify drug concentrations because it yields accurate results and allows for noninvasive collection methods. Prior to excretion, drug metabolites in the body undergo a glucuronidation reaction, resulting in a glucuronide bond that must be cleaved before mass spectrometry (MS) analysis by a β-glucuronidase enzyme hydrolysis. Many laboratories employ a “dilute-and-shoot” method after hydrolysis to decrease residual protein or enzyme concentration, but this method negatively affects column lifetime and reduces the sensitivity of analyte detection. By using a β-glucuronidase removal approach, analysts are able to see an increase in sensitivity and a reduction in MS instrument maintenance.

Simultaneous Quantitation of Buprenorphine and Its Metabolites Using LC–MS

By Anand A. Joshi, Neha V. Maharao, Phillip M. Gerk

An LC–MS method for simultaneous quantification of buprenorphine and three metabolites: norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide.

Sample Preparation

Know Your Sample: Size Matters

By Douglas E. Raynie

The rise of microsampling raises questions about representative sampling.

New Sample Preparation Products and Accessories for 2016

By Douglas E. Raynie

Many of this year’s new products fit into recently identified trends, but one major driver of advances was not in our forecasts.

Partner Organizations


Sepu, China's Largest Chromatography Training Site

About Sepu

News from Sepu


Chinese American Chromatography Association (CACA)

About CACA



ChromAcademy Homepage


Useful Free Tools for HPLC Method Development

By Tony Taylor

I’ve done that thing where I’ve stated a very interesting title—I hope I can deliver something which lives up to it. I dislike it when people “overstate” their talk or poster titles at conferences to draw me in and then don’t deliver against the promise—I’ll let you judge how we go here.

Top-Down Protein Quantitation on a Triple-Quadrupole Mass Spectrometer

By Kevin A. Schug

Top-down protein quantitation, especially using triple-quadrupole MS, but even in general, has hardly been pursued. To help fill this gap, we recently reported a systematic investigation of intact-protein quantitation using multiple reaction monitoring (MRM) on a triple-quadrupole MS system, and we believe that this approach can be a promising alternative route to consider going forward.


LCGC TV player on LCGC homepage

LCGC Slideshows

Slideshow: Seven Common Faux Pas in Modern HPLC

Seven outdated traditional practices that should not be performed without considering alternative approaches that can improve results, provide lower operation costs, or give faster run times. Instead of working harder, analytical scientists should work smarter. Learn more by clicking through the slideshow.

Slideshow: The Top 10 HPLC and UHPLC Column Myths

Webster’s New Collegiate Dictionary defines a myth as “an ill-founded belief held uncritically, especially by an interested group.” Could that group be misinformed chromatographers?

Latest News

Recent Advances in Microfluidic Liquid Chromatography

A publication in TrAC Trends in Analytical Chemistry has covered the recent advances in microfluidic liquid chromatography.

Recent Advances in the Preparation and Application of Monolithic Capillary Columns

Researchers from the China Pharmaceutical University in Nanjing, China, have published a review of the recent advances in the preparation and application of monolithic capillary columns in separation science.

LCGC E-Books

Current Trends in Food Analysis

In recent years, food analysis has blossomed out from a singular focus on food safety to a study of a wide array of questions such as the authentication of food origin and the nutritional aspects of natural food compounds. In this new e-book, we explore some current trends in food analysis and also provide some concrete advice for preparing food samples for analysis.

Go to E-Book Library>>



Is the Art of HPLC Method Development Dead?

CHROMacademy's Tutor Scott Fletcher discusses whether HPLC method development has become a dying art.

How to Optimize the Key Variables in GC Analysis: GC Columns and Detectors

Selecting a gas chromatography (GC) column can be a daunting task. It may seem like there are a never-ending number of phase chemistries, or an inordinate number of column geometry options. However, when choosing a column for a new application (or to improve an existing one) there are some simple rules that can be followed.

lorem ipsum