Jobs in Analytical Chemistry

You may have an excellent educational background, and perhaps some very good experience, too. But are you prepared to get—and keep—your next job in analytical chemistry? This collection of short articles from LCGC’s digital magazine, The Column, offers essential advice for separation scientists who aspire to get a new job and succeed once there.

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Featured LCGC Interviews

Measuring Phytosterols in Fortified Food

A balanced diet is one step closer to a healthy lifestyle. Samantha Duong from the Australian Government’s National Measurement Institute (NMI) has used gas chromatography with flame ionization detection (GC–FID) to measure phytosterols in fortified food. She recently spoke to us about this research.

The Challenge of Accurate Protein Bioanalysis

In recent years, liquid chromatography–tandem mass spectrometry (LC–MS-MS) methods have been increasingly adopted as a replacement for ligand-binding assays to monitor the fate of drugs in vivo. Such bioanalysis of protein-based pharmaceuticals (biopharmaceuticals) is more challenging, however, than it is for small-molecule drugs. Rainer Bischoff of the University of Groningen in the Netherlands has been exploring approaches to overcome these challenges. He recently spoke to us about this work.

Gas Chromatography

Gas Cylinder Safety, Part I: Hazards and Precautions

By John V. Hinshaw

What are the principal hazards and safety issues surrounding high-pressure gas cylinders?

Sealing it with Septa

By John V. Hinshaw

Choosing the wrong septa can compromise method accuracy.

Mass Spectrometry

Practical Considerations of Capillary Electrophoresis–Mass Spectrometry for Analysis of Biotherapeutics

By Sumit Kumar Singh, Vishwanath Hebbi, Anurag S. Rathore, Ira S. Krull

For testing various attributes of proteins, CE–MS is superior to LC–MS. And despite common fears, it is a robust tool. But adapting an LC–MS method to CE–MS requires careful optimization.

Urine Analysis: The Good, the Bad, and the Ugly

By Jenny Cybulski

In clinical and forensic/toxicology laboratories, urine is a preferred matrix from which to quantify drug concentrations because it yields accurate results and allows for noninvasive collection methods. Prior to excretion, drug metabolites in the body undergo a glucuronidation reaction, resulting in a glucuronide bond that must be cleaved before mass spectrometry (MS) analysis by a β-glucuronidase enzyme hydrolysis. Many laboratories employ a “dilute-and-shoot” method after hydrolysis to decrease residual protein or enzyme concentration, but this method negatively affects column lifetime and reduces the sensitivity of analyte detection. By using a β-glucuronidase removal approach, analysts are able to see an increase in sensitivity and a reduction in MS instrument maintenance.

Sample Preparation

Know Your Sample: Size Matters

By Douglas E. Raynie

The rise of microsampling raises questions about representative sampling.

New Sample Preparation Products and Accessories for 2016

By Douglas E. Raynie

Many of this year’s new products fit into recently identified trends, but one major driver of advances was not in our forecasts.

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The LCGC Blog: Allowable Changes to Pharmacopeial HPLC Methods

By Tony Taylor

I started my career working in a Quality Control laboratory. I'm familiar with the constraints that must be imposed to ensure consistent global standards and the pace at which change can be implemented without loss of control either within a business or across an industry. OK—scene set.

The LCGC Blog: Addressing the Complexities of Fuels Using GC–VUV

By Kevin A. Schug

I am quite excited about some recent work we and others have performed related to fuels analysis using gas chromatography and vacuum ultraviolet spectroscopy (GC–VUV).


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Latest News

Characterizing Pigments in Peppers

A group of researchers have characterized carotenoid and chlorophyll in different sweet bell peppers (Capsicum annuum L.) using offline multidimensional supercritical fluid chromatography (SFC) combined with reversed-phase liquid chromatography (LC) for the first time.

Phenomenex to be Acquired by Danaher Corporation

Phenomenex (Torrance, California, USA) has announced that it will be acquired by Danaher Corporation (Washington, D.C., USA), a Fortune 150 science and technology company.


Advancing Metabolic Profiling of Herbal Medicines with LC-HRMS

Friday, October 7th, 2016 

8 am PDT / 11 am EDT / 4 pm BST / 5 pm CEST / 10 am CDT


CESI-MS for Multilevel Characterization of Protein Therapeutics

Wednesday, October 12th, 2016 

8 am PDT / 11 am EDT / 4 pm BST / 5 pm CEST

More Upcoming and On Demand Webcasts>>

LCGC E-Books

Advancing the Science of Medical Cannabis Analysis

The medical use of cannabis is increasing. As a result, there is a pressing need to establish and disseminate rigorous methods for the characterization and routine testing of cannabis. Fortunately, experienced analytical chemists are bringing their expertise to the field. In this new e-book, developed in collaboration with the Cannabis Science Conference, leading experts share their perspectives on the current state of cannabis analysis, explain their contributions to advance it, and outline what is still needed. 

Go to E-Book Library>>



GC Setup Checklist

Whether your GC instrument has only been shut down for a couple of days or has been gathering dust in a corner for a year, follow CHROMacademy's quick checklist to increase performance and reliability.

Fundamentals of LC–MS Chromatography - Video Training Course

This course has been designed for anyone who is either new to LC–MS, or who wishes to expand their current knowledge and understanding about the technique as a whole.

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