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This week, Chromatography Online covered new HILIC-HRMS and GC-MS/LC-MS/MS research on liver cancer biomarkers, orange flavor chemistry, and popcorn acrylamide reduction, alongside industry discussions on PFAS analysis best practices, at-line versus automated systems, HPLC-XRF advances for flame retardant analysis, and concerns over declining chromatography education in UK universities.

Gas chromatography-mass spectrometry (GC-MS) used in a pilot study links maternal diet TFAs to trans fat in breast milk.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) confirms mosquitoes auto-disseminate pyriproxyfen from painted surfaces

Liquid chromatography-mass spectrometry (LC-MS) proteomics shows food levels shape mussel gill heat-stress response.

Summary: A preview of 2026 separation science trends, from PFAS and SFC to metabolomics, next-generation HPLC columns, oligonucleotides, and ADC analysis.

Hans-Gerd Janssen explores the industry's shift from fully integrated online systems to at-line approaches.

Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) links orange flavor and aroma differences to regional climate factors.

Ion chromatography ties chloride levels to heat-enhanced fingerprint clarity.

Micro-liquid chromatography-tandem mass spectrometry (LC-MS/MS) finds no cerebrospinal fluid endocannabinoid link to migraine, but rather to mood.

Does high-performance liquid chromatography (HPLC) analysis show that melittin alone can't predict bee venom quality?

A worrying trend has emerged in UK higher education: the systematic erosion of deep, hands-on chromatography instruction and delivery of this key technique by non-experts, according to Tony Edge, President of The Chromatographic Society (ChromSoc). Can this trend be reversed?

LCGC International spoke to the University of Salerno’s Eduardo Maria Sommella and Danila La Gioia regarding a new hydrophilic interaction liquid chromatography-high resolution mass spectrometry (HILIC-HRMS) method which quantifies circulating analytes to help detect liver cancer.

Gaëlle Spileers from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses developments in high performance liquid chromatography (HPLC–XRF) for the analysis of brominated flame retardants and other pollutants.

The panel closes with a shared message: define your question first, and remember every result is an estimate.

Gaëlle Spileers from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses developments in high performance liquid chromatography (HPLC–XRF) for the analysis of brominated flame retardants and other pollutants.

High-performance liquid chromatography (HPLC)-verified caffeine dose eased mental fatigue from nap deprivation in a recent pilot study.

Chromatography of tooth layers links prenatal pollutants to autism risk.

Frederic Lynen from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses why he worked with Gaëlle Spileers to develop a high performance liquid chromatography X-ray fluorescence (HPLC–XRF) technique to analyze brominated flame retardants and other pollutants.

High-pressure liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) was used to determine whether there is a link between serum PFAS and breast density.

Gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O) pinpoint key odorants behind soybean off-flavor profiles.

Asked for one change to ease PFAS analysis, the panel points to better communication and smarter use of AI tools.

Melissa Dunkle, senior research scientist at Dow Benelux BV, The Netherlands, explores practical aspects of using multidimensional pyrolysis gas chromatography (Pyr-GCxGC) to investigate fluoropolymer degradation.

High-resolution liquid chromatography-tandem mass spectrometry (HRLC-MS/MS) reveals how low-oxygen burials preserve ancient brain proteins.

Soil chromatography reveals how fluridone herbicide persists in cotton farmland.

The experts compare direct injection and solid-phase extraction for handling PFAS in complex matrices.

Gas chromatography-mass spectrometry (GC-MS) reveals how alcohol and acidity shape climate-linked wine aroma compounds.

The panel tackles the paradox of background contamination: the lower detection limits go, the more PFAS turn up everywhere.

Gas chromatography (GC) shows ultrasound-treated pea starch reduces oil in fried corn starch foods.