In this fourth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.
Skipping solid-phase extraction (SPE) cleanup rarely hurt liquid chromatography–tandem mass spectrometry (LC–MS/MS) plant hormone results in tomato.
The panel considers how AI and automation could reshape peptide method development, and why scientific judgment will remain essential.
Gas chromatography–mass spectrometry (GC–MS) and docking reveal A. excelsa leaf compounds that may help in cancer treatment.
Gert Desmet offers his insights on the potential benefits AI/ML could offer the separation science community in the future.
Quantitative non-targeted screening with predicted response factors is not for regulation, but can rank environmental chemicals by concentration and toxicity.
Gert Desmet explores the current role of AI/ML in separation science.
Gas chromatography–mass spectrometry (GC–MS) reveals a four-stage polycyclic aromatic hydrocarbons (PAH) breakdown in oil sludge co-composted with manure.
This new high-performance liquid chromatography-ultraviolet (HPLC-UV) method measures glutathione and thiol levels across 12 berries.
Piotr Alvarez explains how HILIC complements reversed-phase LC for GLP-1 peptides, and why the field is moving toward MS-friendly TFA alternatives.
In this third part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses the retention mechanism of hydrophobic interaction.
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows hydrogel cuts dogs' peak bupivacaine blood levels fivefold.
In the second part of our interview, Novartis's Martina Lioi talks about using IP-HILIC and RP for lipid-siRNA impurities
LCGC International spoke to David Hage, Sanduni Heenkenda, and Zoe Zingler of the University of Nebraska-Lincoln about how green chemistry principles are reshaping affinity chromatography.
Panelists identify the parameters that make or break peptide method robustness and tech transfer, including temperature, flow rate, and dwell volume.
In Part 2 of "Conversations with Michael Dong," the LCGC column editor discusses HPLC columns for pharmaceutical analysis and the case for short columns.
Gas chromatography-mass spectrometry (GC–MS) shows scarlet macaw feather scent varies by sex and mate status.
Martina Lioi pairs IP-HILIC and RP to map impurities in fatty acid–linked siRNAs
Gas chromatography-mass spectrometry (GC–MS) reveals bisphenol A and other lasting pollutants in Maricá Lagoon (Brazil) sediments.
This week, Chromatography Online covered automated GC-MS/MS testing for phthalates in oils, chemicals hidden in bioplastic packaging, troubleshooting tips for oligonucleotides and GLP-1 peptides, automated glycan profiling, NIST reference materials, and the experience of being the only woman in the laboratory.
Multidimensional chromatography cuts ion suppression in complex environmental samples by separating salts and coeluting compounds from target analytes.
The panel discusses quantitative peptide analysis, including drug substance vs. drug product complexity, recovery, and methionine oxidation risk.
Gas chromatography–quadrupole time-of-flight mass spectrometry (GC–QTOF MS) screening of dust finds 269 contaminants in homes, offices, and schools.
Click here to access the LCGC International September/October 2026 European PDF in an interactive format.
Click here to access the LCGC International September/October 2026 North American PDF in an interactive format.
Gas chromatography-mass spectrometry (GC–MS) reveals citral drives inhaled magnolia oil's attack on breast cancer.
The 2026 Gulf Coast Conference (GCC) will be held at the Moody Gardens Convention Center in Galveston, Texas, from October 12–15.
The panel cover protecting peptide recovery, from mobile-phase pH and diluent buffers to inert column hardware.
Henri B. Kagan and Kenso Soai win 2026 Nobel Prize in Chemistry for explaining molecular handedness
Liquid chromatography–tandem mass spectrometry (LC-MS/MS) and sequencing link fungi to Fusarium and Alternaria toxins in barley.
