Identifying PFAS in Soil Samples
October 17th 2024Jonathan Zweigle of the University Tübingen spoke with LCGC International about his work using non-targeted screening based on high-resolution mass spectrometry (HRMS) to detect PFAS in soil samples. HRMS allows scientists to determine the elemental and isotopic composition of a sample with high accuracy.
Characterization of Product Related Variants in Therapeutic mAbs
October 15th 2024Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.
A Well-Written Analytical Procedure for Regulated HPLC Testing
October 15th 2024This paper describes the content of a well-written analytical procedure for regulated high-performance liquid chromatography (HPLC) testing. A stability-indicating HPLC assay for a drug product illustrates the required components for regulatory compliance, including additional parameters to expedite a laboratory analyst’s execution.
Systematic Evaluation of HILIC Stationary Phases for MS Characterization of Oligonucleotides
October 15th 2024Hydrophilic interaction chromatography–mass spectrometry (HILIC-MS) offers a flexible and efficient alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for oligonucleotide analysis, with column selectivity and mobile phase pH being key factors in optimizing retention and detection.
A recent joint study between the Department of Forensic Science of the College of Criminal Justice at Sam Houston State University (Huntsville, Texas) and the Department of Criminal Justice of the School of Social Sciences at Ming Chuan University, (Taipei, Taiwan) developed artificial intelligence (AI) by transfer learning in a convolutional neural network (CNN), GoogLeNet, with the image classification AI fine-tuned to create intelligent classification systems to discriminate samples containing gasoline residues from burned substrates.