Application Notes

As biopharmaceutical pipelines diversify, laboratories must deliver reliable, high-quality data across increasingly complex sample types. Download this eBook to explore how next-generation liquid chromatography (LC) systems are enabling robust, flexible bioanalysis through real-world QC applications.

Lorna De Leoz, Agilent Global Food Segment Director, addresses the growing concern surrounding per- and polyfluoroalkyl substances (PFAS) in food supply. These “forever chemicals” accumulate in the environment and in people, and are associated with serious health risks including cancer and immune suppression. PFAS are notoriously difficult to detect and remove because they originate from multiple sources (water, soil, packaging) and encompass nearly 15,000 individual compounds. Because of their pervasive nature, laboratories must meet extremely low detection limits, meaning robust analytical testing is essential to managing exposure. Agilent is helping the industry address these challenges with simplified, scalable, end-to-end testing solutions, such as pass-through cleanup workflows and clean components, that reduce contamination risk and help laboratories stay ahead of regulatory demands.

Download Part 4 to explore complete protocols, recovery data, and matrix-specific insights — closing out the full PFAS testing series.

Download Part 3 to explore complete method protocols, performance data, and insights for PFAS analysis in soils and sediments. Part 4 will cover PFAS analysis in fish and animal tissue samples.

Download Part 2 to explore proven workflows, SPE enhancements, and field-tested results. Stay tuned for Parts 3 and 4, covering tissue and solid matrix applications.

Download Part 1 now to explore method optimization strategies, validation protocols, and best practices for reliable PFAS quantification. Parts 2–4 will cover additional sample matrices including wastewater, animal tissue, solids, and biosolids.

Download the technical note to see how QSight redefines LC/MS/MS robustness for food labs handling PFAS analysis at scale.

Improve prep LC performance and recovery. See how MaxPeak Premier OBD Columns help isolate B vitamins and unknowns by minimizing metal surface interactions.

Innovation is the engine that powers a company’s growth and product development, and for enterprises with R&D laboratories, those lab environments are the greatest source of this innovation. In this white paper, learn how a platform approach to scientific data management, including semantic search, advanced analytics, and lab automation, leads to better enterprise decisions at the executive level, optimized lab performance, more discoveries, and stronger product pipelines.

As today’s labs continue to evolve, the software solutions that support them must too. Likewise, laboratory and organization leadership must be open to the advancements available to them from modern technologies. In this white paper, learn how a SaaS-based LIMS modernization program optimizes data management, fosters collaboration, and improves decision-making to stay at the forefront of scientific innovation.

Permeation tubes are used in various applications for creating trace concentration gas standards for calibrating gas analytical devices such as a gas chromatograph.

An overview of the untargeted PFAS analysis workflow capabilities within Thermo Scientific Compound Discoverer Software using the Orbitrap Exploris Mass Spectrometer.

The waters_connect™ System Monitoring is the latest innovation in lab management, providing real-time information for all Empower-controlled chromatography systems via the waters_connect cloud platform. Coordinating laboratory work and responding dynamically to changing priorities has never been easier.

This application note describes how Medtronic has created a data-handling workflow for chemical characterization and database curation.

This app note demonstrates a comprehensive software workflow for non-targeted analysis of per- and polyfluoroalkyl substances by high-resolution mass spectrometry.

In this app note, we evaluate the performance of the novel Orbitrap Astral mass spectrometer for plasma proteomics using 4 of the most common plasma sample prep methods

Clinical Research: Streamlined workflow and minimum up-front development efforts using the first commercial ready-to-use kits for quantitative analysis of mAbs

Comparison of analytical methods for quantification of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 on a Thermo Scientific™ TSQ Altis™ MD mass spectrometer

This tech note presents a low-input proteomics sample workflow using the Pierce HeLa protein digest standard in nanogram and picogram loads on the Orbitrap Astral mass spectrometer

This application note discusses an advanced sensitive, reproducible and efficient single-cell measurement and sample throughput workflow platform.