Best of the Week: Inside the Grinias Lab, ACS Satinder Ahuja Award
Here are the top five articles that the editors of LCGC International published this week.
This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
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In the Lab: Grinias Research Lab at Rowan University, Part I – Jim Grinias Interview
Patrick Lavery
This latest edition of our Inside the Laboratory series gives us an in-depth look at the laboratory of James Grinias, a professor in Rowan University’s Chemistry and Biochemistry Department. Jim’s work has frequently been featured in the publications under the LCGC International umbrella, and we have also featured him in various conference video interviews. The Grinias Research Lab has supplied portable liquid chromatography (LC) and mass spectrometry (MS) systems to the pharmaceutical industry, and recently the laboratory received funding from the United States Army to use small-scale LC–MS instrumentation to study and detect signs of post-traumatic stress disorder (PTSD) in the blood of service members. In this video interview, Grinias discusses his background, teaching philosophies, students, and lab equipment.
Chinese Herbal Medicine Analyzed for Its Effectiveness in Treating PCOS,
Aaron Acevedo
A recent study out of Zhejiang University and Zhejiang GongShang University in Zhejiang, China had scientists analyzing Cang-Fu-Dao-Tan Formula (CFDTF), a Chinese herbal medicine, to determine what makes it effective in treating polycystic ovary syndrome (PCOS). PCOS is a common endocrine disease that can affect between 5–18% of reproductive-age women, with the exact cause of the disease being unclear. CFDTF, which is a mix of nine Chinese herbs, has been useful in combatting PCOS. However, the medicine’s effects on glucose metabolism, reproductive hormones, and blood lipids needed examining for adverse effects. For this study, the scientists used techniques like ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) to clarify how CFDTF specifically treats PCOS.
Pittcon 2024: An Interview with Tom Linz
Patrick Lavery
Tom Linz is a widely recognized scientist who was the 2023 recipient of the ACS Analytical Division Satinder Ahuja Award for Young Investigators in Separation Science. Currently serving as an Assistant Professor of Chemistry at Wayne State University, Linz leads his own laboratory that develops “innovative” lab-on-a-chip technologies. These devices integrate sample preparation, preconcentration, and different analytical technologies like microchip electrophoresis and immunoassays. Linz’s team hopes that these integrations can enhance biochemical measurements and surpasses conventional instrumentation capabilities. In this video interview from Pittcon 2024, Linz discusses his presentations at Pittcon 2024, what the Satinder Ahuja Award means to him and his career, and what is coming next for him and his team.
Analytical Chemistry’s Role in Science
William Wetzel
Analytical chemistry can be applied in various fields, from food analysis to pharmaceuticals and beyond. However, amongst the public, analytical chemists can go unrecognized for their contributions. In a recent Analytical and Bioanalytical Chemistry article, Erwin Rosenberg of Vienna University of Technology and Rudolf Krska of the University of Natural Resources and Life Sciences, Vienna (BOKU) discussed how analytical chemistry has influenced different scientific disciplines; namely, life sciences, material sciences, and environmental science. First, they look through the history of analytical chemistry in the respective fields. Then, they discussed how analytical chemistry evolved from being viewed as an “enabling science” to being its own discipline that has not received enough recognition by the broader scientific community.
A Review of Advancements in Detecting New Psychoactive Substances
LCGC Staff
Illegal narcotics and other drugs are becoming an international concern, with new drug policies needing to form regulations on these new psychoactive substances (NPS). NPS are drugs meant to mimic established illegal narcotics, such as cannabis, MDMA, LSD, and cocaine, though these drugs’ chemical structures are meant to circumvent the drug policies of different countries’ manufacturers. NPS use is linked to numerous health issues, such as seizures, and using these substances can potentially lead to dependencies in some people. Scientists are thusly working to refind methods to detect and identify these compounds. In a recent Analytical and Bioanalytical Chemistry review, Bartlomiej Feigel from the Jan Sehn Institute of Forensic Research and Krakow University of Technology discussed how analytical techniques are being used to combat the rise in designer drugs.
TD-GC–MS and IDMS Sample Prep for CRM to Quantify Decabromodiphenyl Ether in Polystyrene Matrix
April 26th 2024At issue in this study was the certified value of decabromodiphenyl ether (BDE 209) in a polystyrene matrix CRM relative to its regulated value in the EU Restriction of Hazardous Substances Directive.
LC–MS/MS-Based System Used to Profile Ceramide Reactions to Diseases
April 26th 2024Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
