At Pittcon 2024, LCGC International editor Patrick Lavery sat down with John R. Yates of the Scripps Research Institute to talk about his work in mass spectrometry and proteomics.
John R. Yates is the Ernest W. Hahn Professor at the Scripps Research Institute in La Jolla, California, specializing in Molecular Medicine & Neurobiology. He is renowned for his work in tandem mass spectrometry analysis of protein mixtures, mass spectrometry bioinformatics, and proteomics-related biological studies.
Yates is credited with inventing the SEQUEST software for correlating tandem mass spectrometry data with sequences in databases and pioneering the shotgun proteomics technique for analyzing protein mixtures. His laboratory has developed proteomic methods for studying protein complexes, posttranslational modifications, organelles, and quantitative protein expression analysis.
Click here for a recap of Yates' lecture from this year's Pittcon.
Yates has received numerous awards, including the ASMS Biemann Medal, HUPO Achievement Award, Christian Anfinsen Award (Protein Society), Analytical Chemistry Award (ACS), Ralph N. Adams Award, Thomson Medal (IMSF), John B. Fenn Award (ASMS), and HUPO Discovery Award. Currently, he serves as the editor-in-chief of the Journal of Proteome Research.
LCGC International sat down with Yates at Pittcon, held this year a short drive from La Jolla in San Diego, to discuss the following topics:
TD-GC–MS and IDMS Sample Prep for CRM to Quantify Decabromodiphenyl Ether in Polystyrene Matrix
April 26th 2024At issue in this study was the certified value of decabromodiphenyl ether (BDE 209) in a polystyrene matrix CRM relative to its regulated value in the EU Restriction of Hazardous Substances Directive.
LC–MS/MS-Based System Used to Profile Ceramide Reactions to Diseases
April 26th 2024Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.