The Future of Mass Spectrometry

Register Free: https://www.chromatographyonline.com/lcgc_w/ASMS

Event Overview:

Join us for this virtual symposium as we explore the future of mass spectrometry (MS) technology. Technical talks from scientists at leading mass spectrometry instrument manufacturers will bring you up to date on important developments, including many announced at the ASMS 2022 event. They will explain and demonstrate the technologies underlying advanced capabilities of mass spectrometry techniques and instruments, addressing how those capabilities can translate into performance improvements such as increased sensitivity, greater robustness, and ease-of-use. They will also describe advances in practical applications of mass spectrometry techniques, illustrating the work with real examples and data. You will be able to ask all your questions, too. Are you missing the opportunity to explore new products hands-on at a live event? Are you finding online videos too brief, and craving the opportunity to ask your specific questions? This event will give you the answers you seek. Sign up today!

Key Learning Objectives:

• Get up to speed on the latest in mass spectrometry technology
• Understand where mass spectrometry tools are heading
• Gain practical information to make your work easier and more effective

Agenda

10:00am – 10:30am Keep Running, Take the Lead: Introducing New GC Single Quadrupole and GC Triple Quadrupole Instruments
Lakshmi Krishnan, GC/MS Single Quadrupole Product Manager, Agilent Technologies and Joel Ferrer, GC/MS Triple Quadrupole Product Manager, Agilent Technologies

High-throughput laboratories in the environmental and food industries face constant pressure to analyze more samples, even as resources shrink and analytical challenges grow. New developments in intelligence and performance raise the gold-standard in gas chromatography–mass spectrometry (GC/MS) to handle the complexity and demands of routine testing. In this presentation, we will focus on new technology advancements and best practices in GC/MS that reduce downtime and enhance lab productivity and performance. We will also highlight overcoming the challenges due to helium shortage without compromising on system performance.

10:30am – 11:00am: The Brains of the Operation – A Smart LC/MS/MS for Challenging Routine Analysis
Patrick Batoon, Product Manager of Triple Quadrupole LC/MS, Agilent Technologies, Mass Spectrometry Division

Although we’re unable to make self-operating mass spectrometers yet, we can intelligently automate difficult and challenging tasks, making mass spec more accessible. The new Agilent 6475 triple quadrupole LC/MS with MassHunter 12 brings about exciting new changes to targeted LC/MS instrumentation by adding easy-to-use, yet sophisticated onboard intelligence for routine analysis. This presentation will cover the new intelligence features, and how they improve analytical performance and lab productivity, and provide peace of mind for day-to-day operation.

11:00am-11:30am: Combining an Optical Microscope with a High-End Mass Spectrometer for a Seamless Imaging Experimental Workflow
Nazim Boutaghou, PhD, Product Manager, Life Science, Shimadzu Scientific Instruments

Mass spectrometry imaging (MSI) is arguably the most challenging application in mass spectrometry. The demands of the application require instrument manufacturers to design instruments that push physics limits while keeping the instruments easy to use and rugged. Users in the field are also challenged by their goals and sample preparation that requires attention at every step. Shimadzu Corporation has recently launched a new Imaging Mass Microscope that incorporates two key instruments for imaging experiments: a high-end microscope and an ultra-fast Q-TOF mass spectrometer. The result is a unique workflow and user experience that enables scientists to obtain accurate images in no time. In this presentation, we will discuss the basics of an imaging experiment, its limitations, and how Shimadzu’s comprehensive imaging platform can help new and existing MSI users overcome those limitations.

11:30am-12:00pm: Rapid and Complete Reduction of All Disulfide Bonds in mAbs Using On-line Electrochemistry–MS
Jean-Pierre Chervet, CEO, Antec Scientific

The rapid electrochemical reduction of both intra- and interchain disulfide bonds in different mAbs will be presented using electrochemical reduction inline with a high-resolution accurate mass liquid chromatography–mass spectrometry (HRAM LC–MS) system. At a potential of 1 V, at 60 °C, complete reduction is achieved, without modification of the LC–MS method other than the introduction of the electrochemical cell and the trap/release switching step. The developed workflow reduces an antibody down to light and heavy chain subunits without the need for enzymes or denaturing or reducing agents. Furthermore, the selectivity of the electrochemical S-S bond reduction by tandem MS could provide information about non-uniform disulfide bonding structures within mAbs.

12:00pm-12:30pm: Microchip CE-MS – A Versatile Platform for Analysis of Small Molecules, Intact Proteins, and Beyond
Adi Kulkarni, Ph.D, Applications Scientist, 908 Devices

ZipChip is a microchip-based device that integrates capillary zone electrophoresis (CZE) with nano-electrospray ionization and can be seamlessly coupled with mass spectrometry to enable fast and easy CE-MS analysis. With ready-to-use chip and reagent kits provided, the need for method development for standard applications is minimized. The platform can be used for applications ranging from proteins and peptides in biopharmaceuticals, oligonucleotides, and AAVs in cell and gene therapy applications, and for multiomics applications such as proteomics and metabolomics. This presentation will provide an overview of the microchip CE-MS technology and cover the fundamental concepts behind how the platform functions. The presentation will also show application examples of using the microchip platform on a wide range of analytes including amino acids, native proteins and oligonucleotides.

Speakers

Lakshmi Krishnan
GC/MS Single Quadrupole
Product Manager
Agilent Technologies

Joel Ferrer
GC/MS Triple Quadrupole
Product Manager
Agilent Technologies

Patrick Batoon
Product Manager of Triple Quadrupole LC/MS
Agilent Technologies, Mass Spectrometry Division

Nazim Boutaghou, PhD
Product Manager, Life Science
Shimadzu Scientific Instruments

Jean-Pierre Chervet
CEO
Antec Scientific

Adi Kulkarni, Ph.D
Applications Scientist
908 Devices

Register Free: https://www.chromatographyonline.com/lcgc_w/ASMS