Dwight R. Stoll is the editor of “LC Troubleshooting”. Stoll is a professor and the co-chair of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, USA. His primary research focus is on the development of 2D-LC for both targeted and untargeted analyses. He has authored or coauthored more than 75 peer-reviewed publications and four book chapters in separation science and more than 100 conference presentations. He is also a member of LCGC’s editorial advisory board. Direct correspondence to: amatheson@mjhlifesciences.com
Essentials of LC Troubleshooting, Part 4: What is Going On with the Baseline?
October 1st 2022Some liquid chromatography (LC) troubleshooting topics never get old because there are some problems that persist in the practice of LC, even as instrument technology improves over time. There are many ways for things to go wrong in an LC system that ultimately manifest as detector baselines that do not look right. Developing a short list of the likely causes of these results can help streamline our troubleshooting experience when baseline-related problems occur.
The 13th Multidimensional Chromatography Workshop: Why Does Multidimensional Chromatography Matter?
January 14th 2022The 13th Multidimensional Chromatography Workshop is a free virtual event involving keynote presentations, contributed presentations, and discussion groups, and is happening virtually on 31 January–2 February 2022.
The 13th Multidimensional Chromatography Workshop: Why does Multi-dimensional Chromatography Matter?
December 1st 2021The 13th Multidimensional Chromatography Workshop is a free event involving keynote presentations, contributed presentations, and discussion groups on all multi-dimensional techniques happening virtually on January 31, 2022 - February 2, 2022.
Retention Factor is Independent of Pressure in Liquid Chromatography, Right?
October 1st 2021Understanding when the effect is likely to be large enough to affect resolution is valuable for troubleshooting unexpected results that arise during both method development and the execution of established methods.
But My Peaks Are Not Gaussian! Part 2: Physical Causes of Peak Asymmetry
September 1st 2021Several physical phenomena can lead to asymmetric peak shapes, including heterogeneity of the particle density inside the column, rearrangement of the particles over time, and accumulation of debris at the column inlet frit. This month’s instalment will focus on these potential physical causes.