Mass Spectrometry

Jul 01, 2016
Special Issues
This study of a selected group of PPCP contaminants in eastern North Carolina demonstrates the advantages and disadvantages of LC–MS and GC–MS as well as SPE and liquid–liquid extraction.
Jul 01, 2016
Special Issues
An LC–MS method for simultaneous quantification of buprenorphine and three metabolites: norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide.
Jul 01, 2016
LCGC North America
This direct-analysis MS method is more accurate than immunoassay screening and requires no special instrumentation.
May 01, 2016
Special Issues
A review of the central role LC–MS plays in characterizing mAbs and biosimilars, including highlights of top-down and middle-up approaches to measure the intact masses of mAbs and their subunits, the current state of peptide mapping techniques, and glycoprofiling methods.
May 01, 2016
Special Issues
The development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
May 01, 2016
Special Issues
Measuring trypsin inhibitors in legumes is important to feed processors, who are concerned with providing high-quality products for animal feed. In this study, a rapid, accurate, and precise method for the quantification of trypsin inhibitor activity is evaluated.
May 01, 2016
Special Issues
High-resolution mass spectrometry (MS) is not readily compatible with chromatographic techniques using high-salt mobile phases. This study presents the development and use of 2D-LC–MS via an on-line desalting step for the analysis of monoclonal antibodies and antibody–drug conjugates.
May 01, 2016
Special Issues
A newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Apr 01, 2016
LCGC North America
The three key applications for desorption and ionization techniques are rapid, in situ screening; direct analysis of extracted samples or planar chromatography spots; and scanning samples along x and y axes.
Mar 01, 2016
Special Issues
This article provides useful tips for smooth validation of multi-analyte LC–MS-MS methods and summarizes important validation outcomes for 295 analytes, including more than 200 mycotoxins.
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