April 26th 2024
Here are the top five articles that the editors of LCGC International published this week.
Inside the Laboratory: The Yang Group of the University of Oklahoma
January 16th 2024In our second edition of “Inside the Laboratory,” Zhibo Yang, PhD, an associate professor of chemistry at the University of Oklahoma, discusses his group’s most recent work in single-cell mass spectrometry (MS) and MS tissue imaging.
Synthesizing Synthetic Oligonucleotides: An Interview with the CEO of Oligo Factory
January 15th 2024LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.
This review article discusses scientific rationales and current best practices in the pharmaceutical industry for performing chromatographic peak purity assessments (PPA). These activities are associated with the development and validation of liquid chromatographic (LC) stability-indicating analytical methods applicable to regulatory submissions of small-molecule drug candidates. The discussion includes a comprehensive overview of the PPA-related regulatory and scientific landscape and common industry approaches to obtain PPA results, as well as the strengths and weaknesses of PDA-facilitated ultraviolet (UV) PPA and other PPA techniques.
Flow-Injection MS Selectively Ionizes Oxidized Triacylglycerols Versus Non-Oxidized Precursors
December 15th 2023While lipid oxidation in food is a serious problem, lipid species in both oxidized and non-oxidized forms at varying concentrations make detection and identification of the less abundant species difficult.
UHPLC–MS Method Used to Detect Purine Metabolites and Study Severe Biological Disorders
December 5th 2023A recent study published in the Journal of Separation Science reveals how ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) could be used to detect and quantify purine metabolites.
Untargeted Analysis in Petroleomics
December 1st 2023LCGC spoke to Leandro Wang Hantao from the University of Campinas in São Paulo, Brazil, about his work investigating the influence of ion management parameters on the data produced by comprehensive gas chromatography–high-resolution mass spectrometry (GC×GC–HRMS) equipped with a fourier transform-orbital ion trap mass analyzer, and his investigation into employing channel occlusion for sample preparation in untargeted analysis in petroleomics.