May 14th 2024
Scientists from the Shenyang Pharmaceutical University in China have developed a new quality assessment system for various types of traditional Chinese medicine (TCM).
The LCGC Blog: Critical Evaluation of Chromatography Methods—Essential Detective Skills
October 12th 2021In this series of blog posts, I’m going to explore how the challenges of adopting methods from the literature, or from internal or external clients, can often be made easier, and more enjoyable, by taking time for some detective work prior to even entering the laboratory.
Novel 3D-Printing Method to Create Liquid Chromatography Columns
September 1st 2021Three-dimensional (3D) printing shows promise for creating stationary phases with tailored geometries. We present a method that overcomes limitations of other approaches, and can produce columns with a feature resolution of 10 μm.
The LCGC Blog: Back to School—Solving Practical HPLC Problems with Basic Theory
July 6th 2021I’m very much a “big picture” type of thinker. By that, I mean unless I can understand all of the working parts of a problem and understand how they interact, I find it difficult to decide the best approach to figuring out how to solve the issue.
Non-Targeted Analysis of PFAS in Surface Water Using Fragment Ion Flagging
June 1st 2021Per- and polyfluoroalkyl substances (PFAS) in surface water have become a major concern due to their persistency and toxicity. We recently spoke to Stefan Van Leeuwen and Bjorn Berendsen of Wageningen Food Safety Research (WFSR), in The Netherlands, about their novel research into non-targeted PFAS screening using an LC–HRMS method with fragment ion flagging.
An Ant-Man Perspective for Chromatography: My Stochastic World
June 1st 2021The stochastic theory of chromatography allows one to connect mathematics to separation science in an intelligible form. We take a “walk” through the column at the level of an Ant-Man, where we can see that chromatography is mathematics and mathematics is chromatography!
Six Key Differentiators Between Liquid Chromatography and High-Resolution Ion Mobility
May 1st 2021Using ion mobility, analytes that have the same molecular mass can be separated by their shape, centers of mass, and collision cross section, but challenges such as ion loss can still occur. A new development in ion mobility separation, high-resolution ion mobility (HRIM), addresses such problems, and is particularly well suited to challenging applications, such as glycosylation monitoring of biological drugs and vitamin D analysis.