May 15th 2024
Scientists from Vanderbilt University recently tested a new means of imaging mass spectrometry (IMS) for isotopically resolved intact proteins.
New Analytical Method Enables Multi-Class Analysis of Pesticides in Corn Products
May 23rd 2023A new study introduces a comprehensive two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC–MS/MS) method for the analysis of 112 pesticides in corn-based products. The method exhibits high precision, lower limit of quantification values, and successful detection of trace levels of pesticides in real samples, offering promise for the analysis of complex matrices.
Ink Source Prediction and Assessment Made Possible by Mass Spectrometry
May 22nd 2023Scientists have developed a new method for predicting and assessing the source of black inks using direct analysis in real-time mass spectrometry. By applying dimensionality reduction techniques and likelihood ratio analysis, the researchers achieved high accuracy in identifying ink sources, demonstrating the potential of this approach in forensic ink analysis.
LC–MS/MS Helps Detect ε-(γ-glutamyl) Lysine as Transglutaminase 2 Biomarker in Human Urine
May 19th 2023A biomarker with significant clinical and analytical potential in an enzyme present in many human diseases was determined at higher efficiency using liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS).
An Interview with AI About Its Potential Role in Separation Science
May 17th 2023We interviewed an AI program (ChatGPT) for LCGC North America asking questions about AI and its role in various applications for separation science to include data analysis, and high performance liquid chromatography (HPLC), hydrophilic-interaction chromatography (HILIC), reversed-phase liquid chromatography (RPLC), liquid chromatography–mass spectrometry (LC–MS), gas chromatography–mass spectrometry (GC–MS), high resolution mass spectrometry (HRIM–MS), high resolution tandem mass spectrometry (HRMS/MS), and related topics.
New Tool for Authenticating Single Herbal Powders
May 15th 2023Scientists have developed an automatic and highly efficient method to authenticate single herbal powders using microscopy-guided in situ auto-sampling combined with matrix-assisted laser desorption–ionization mass spectrometry (MALDI–MS).
New Framework Expands Isomer Identification Possibilities with Mass Spectrometry
May 15th 2023New statistical framework developed by researchers at the University of California in Riverside allows confident identification of isomeric molecules by mass spectrometry, even when no unique mass-to-charge peaks are generated between the isomeric pairs.
Rising Stars of Separation Science: Juan L. Benedé
May 9th 2023This month we interview Juan L. Benedé from the University of Valencia in Spain, about his work developing microextraction approaches, based on the use of sorbent materials, for application to complex matrices, and his focus on the determination of disease biomarkers in biofluids.
New Ultrasensitive LC–MS/MS Method Allows for Accurate Melatonin Quantification in Human Saliva
May 8th 2023A new study reports the development a highly sensitive LC–MS/MS method to measure salivary melatonin levels. The method has a lower limit of the measuring interval of 0.8 pg/mL, making it the most sensitive method for quantifying melatonin in saliva.
Study Finds That Using Seven Points Across a Peak Is Sufficient for Accurate LC–MS/MS Quantitation
May 8th 2023A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.
SPME Arrow Improves Upon Conventional SPME in GC×GC–MS Analysis of Whiskey Flavor Compounds
May 5th 2023A solid-phase microextraction (SPME) Arrow combined with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) identified about 40 more volatile compounds in a variety of whiskeys compared to conventional SPME.