May 3rd 2024
Researchers have utilized ultra-high performance liquid chromatography-tandem mass spectrometry (UH PLC-MS/MS) to monitor 5-Fluorouracil, a medication used to treat various cancers, in dried blood spots. This process offers a simpler, more efficient method than those in place involving the monitoring of plasma.
Reference Materials - Why Quality Matters
June 22nd 2012Access to a comprehensive source of certified reference materials in various forms - powders and solutions - is vital for clinical and forensic laboratories, to ensure the correct identification of substances and the accuracy of results, and there is an increasing customer demand for ISO Guide 34:2009 certification. Jenny Button, Product Specialist, LGC Standards, UK, discusses certified reference materials and the importance of ISO Guide 34 to both manufacturers and end-users.
Quantitative Analysis of Drugs of Abuse in Urine Using UHPLC Coupled to A TOF Mass Spectrometer
June 22nd 2012Human beings have long consumed mind altering drugs to attain a euphoric high. These illegal drugs are obtained directly from natural substances including plants or they are chemically synthesized. Monitoring consumption of abused drugs is important in workplace settings, crime scene investigations, forensic toxicology and other related areas.
Strategies for Rapid Chiral HPLC Method Development for Pharmaceutical Analysis
April 19th 2012Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes.
Liposome Characterizatio by FFF–MALS–QELS
February 1st 2012Liposomes are made of lipid bilayers and are often used in drug delivery by encapsulating the core with therapeutic drugs. During liposome research, formulation, manufacturing, and quality control, it is of great importance to monitor liposome size and encapsulation.
LC–MS-MS Method for the Determination of Enalapril and Enalaprilat fro Human Plasma Using SOLA
February 1st 2012A liquid chromatography tandem mass spectrometry method for enalapril and enalaprilat from human plasma has been developed using Thermo Scientific SOLA cartridges. Sample preparation is fast, efficient, and reproducible giving excellent recovery levels for each compound.
New HPLC/UHPLC Assay Methods for Impurities in Tetracycline
February 1st 2012Tetracycline (TC), a common antibiotic used to treat urinary tract infections, acne, gonorrhea, and other conditions, yields a toxic degradation product, 4-epianhydrotetracycline (EATC). General Chapter 226 of the U.S. Pharmacopeia and National Formulary (USP-NF), referred to by monographs for epitetracycline and drug products containing tetracycline hydrochloride (TC-HCl), prescribes an antiquated assay for EATC impurity in TC.