Market Profile: UHPLC
Ultrahigh-performance liquid chromatography (UHPLC) systems are designed to take full advantage of smaller particles (sub 2 μm), which yield higher resolution and increased sensitivity. Because of increased back pressure, UHPLC systems employ high-performance pumps that deliver 15 000 psi (1,000 bar) or more of pressure. Some systems solve the back-pressure issue by elevating temperatures using a column oven, which lower the viscosity of the mobile phase, allowing it to move faster through the column. UHPLC systems have been shown to provide analysis times of less than 1 min and up to 40 times faster than conventional HPLC systems.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
Traditional Chinese Medicine’s Effects on Liver Cancer Measured Using New UHPLC–QTOF-MS System
April 22nd 2024Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.