Application Notes: LC
Fundamentals of Oligonucleotide Separation by HPLC
July 15th 2020From siRNA to mRNA to DNA, separating full length product from impurities can be challenging. Taking into consideration the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use to characterize or purify your molecule.
Physico-chemical Parameters of Liposomal Doxorubicin Assessed by EAF4–MALS
June 19th 2020Doxorubicin is a well-established chemotherapeutic agent frequently used in cancer treatment. Here we present the application of Electrical Asymmetrical Flow Field-Flow Fractionation (AF4) coupled with Multi Angle Light Scattering (MALS) to derive essential physico-chemical parameters, such as size distribution and surface charge, of a commercial liposomal Doxorubicin formulation.