Liquid Chromatography (LC/HPLC)

HRIM-MS has shown unique capabilities when used to analyze cyclic peptide therapeutics, and enhances the analysis of biopharmaceuticals by efficiently filtering out interfering compounds for direct analysis within a complex mixture. These findings demonstrate the technique's utility and versatility.

An examination of how chromatography could be used to solve the water crisis in the American southwest.

Scientists from China Pharmaceutical University developed a liquid chromatography-tandem mass spectrometry (LC–MS/MS)-based method for determining the presence of anti-colorectal cancer drugs in human plasma.

In this edition of "The LCGC Blog," Jonathan Shackman discusses the differences between chromatographers and chromatography users, as well as advancements that have made chromatography a more accessible field.

Scientists from the Chinese Academy of Inspection and Quarantine recently published a review on how green solvents can further the evolution of microextraction techniques.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.

Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.

The serum/plasma estradiol is useful for diagnosis, pathology, and therapeutic efficacy monitoring of estrogen-dependent diseases, according to the authors.

Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.

On the occasion of Earth Day, University of Wisconsin-Madison graduate student and chemist Katelyn Michael speaks with LCGC about the methods she has been using to attempt to degrade known PFAS.

In this interview, Angela Calderón of Auburn University discusses the importance of using more environmentally friendly analysis techniques.

A 10-day exhibit at Milan Design Week in Italy is drawing to a close, but Shimadzu hopes that visitors have recognized the link between science and technology, and art and design.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the Netherlands created a new LC–MS/MS assay to test new small molecular inhibitors (SMIs) and their effectiveness in prognosing lung cancer.

Here are the top five articles that the editors of LCGC International published this week.

Michelle Colgrave of Edith Cowan University and Australia’s national science agency is the recipient of the 2024 Harvey W. Wiley Award.

French scientists recently created a new analytical method for quantifying micropollutants in different species of gammarids.

Chromatographic and spectroscopic techniques alike were reviewed for their current effectiveness and future potential in this lecture session at Analytica 2024.

The analogy that electrons flowing in wires is like water flowing through a tube can be remarkably effective. In this installment, the basics of that analogy are discussed.

This article describes newly introduced high-performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products in 2023–2024. It summarizes their technical specifications and significant user benefits.

This article examinations the determination of retention time and why it's important.

In this interview, Kevin Schug discusses his work using untargeted analysis and differentiation of psilocybin mushroom strains.

Here are the top five articles that the editors of LCGC International published this week.

The 26th Norwegian Symposium on Chromatography was held 21–23 January 2024. The symposium has strong traditions in the Norwegian separation science community, serving as a forum for excellent scientific talks, networking, and social events.

A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.

Scientists from Auburn University recently investigated how natural deep eutectic solvents (NADES) can be incorporated into high-performance liquid chromatography (HPLC) mobile phases.

Scientists recently tested a new system for detecting and extracting favipiravir from plasma samples.

Scientists from the Affiliated Hospital of Putian University recently analyzed the dysregulation of lipid metabolism in patients suffering from chronic hepatitis B patients.

This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!