Application Notes: Sample Prep
Analysis of Synthetic Cannabinoids in Urine
This application note outlines a solid-phase extraction (SPE) and LC-MS/MS method for the analysis of 19 synthetic cannabinoids in urine
Chloroquine, Hydroxychloroquine, and Desethylchloroquine in Urine
This application note describes a simple and robust solid-phase extraction (SPE) procedure for Chloroquine, Hydroxychloroquine, and Desethylchloroquine in urine.
Extraction of Loperamide and N-Desmethyl Loperamide from Blood
This application note outlines a simple 3 step method for the extraction of Loperamide and its main metabolite, N-desmethyl Loperamide, from blood using UCT’s Clean Screen® XCEL I SPE columns.
Method Validation for Atrazine Analysis
A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.
Analysis of Challenging Polar Contaminants in Water
Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.
Analysis of PPCPs in Drinking Water
A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.
How to Avoid Contamination in Pipetting
Preventing aerosol contamination during pipetting helps you achieve reliable results. Here we address the main contamination mechanisms that need to be avoided.
Extraction of EPA Method 625.1 Semi-Volatile Analytes from Wastewater
Learn how automated solid-phase extraction (SPE) streamlines the analysis of semi-volatile organic compounds in wastewater, in compliance with U.S. EPA Method 625.1.
Improved Aroma Profiling of Breakfast Cereal by Automated High-Capacity Sorptive Extraction
The use of high-capacity sorptive extraction with multi-step enrichment, for enhancing the analysis of VOCs, that contribute to the aroma & flavor of breakfast cereals
Empore SPE Disk for EPA 1664
The performance of the Empore oil and grease solid-phase extraction disk under EPA Method 1664, while reducing the total volume of n-hexane by 40%, is demonstrated.
Enhancing Headspace Analysis for the Food Industry
This application note demonstrates the benefit of large volume preconcentration (LVP) for enhancing headspace analysis of trace-level VOCs that contribute to aroma & flavour in tomato paste.
Protein Precipitation Microplate
This short application note demonstrates the effectiveness of the Microlute™ Protein Precipitation Plate for the removal of proteins.
Amino Acids Analysis by European Pharmacopeia
Amino Acids analysis method according to European Pharmacopoeia to support development and production of biopharmaceuticals.
Perfluoroalkyl and Polyfluoroalkyl Substances in Food
This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.
Structural Analysis and Identification of Sialyl Linkage Isomers
This application note shows an example of N-linked Glycans in which sialic acid residues were stabilized by using the sialic acid linkage specific alkylamidation method.
Identifying and Quantifying Aspartate and Iso-Aspartate Isomers and Other Difficult PTMs in Proteins
CE–MS can help address limitations associated with traditional LC–MS CE–MS provides fast separations with low sample consumption and no carry over
Sensitive Profiling of IgG1 Monoclonal Antibody Variants Under Native Conditions
In this study we demonstrate the benefits of the Thermo Scientific™ Orbitrap Exploris™ 240 LC–MS/MS for intact biopharmaceutical analysis under native conditions.
Real-Time Search data acquisition provides real-time solutions
In this application note we evaluate the benefits of Real-Time Search for SPS MS3 (Orbitrap Eclipse MS) to enhance TMT quantification accuracy and proteome coverage.
A Multiresidue Method for Pesticide Profiling Using an Orbitrap Tribrid Mass Spectrometer
In this application note we discuss the AcquireX workflow using the Orbitrap ID-X for detection and quantitation in non-targeted, multiresidue LC–MS pesticide profiling.
Screening for Neutral Drugs of Abuse in Oral Fluid
This featured application note utilizes UCT’s polymeric Styre Screen® HLD sorbent for the analysis of a wide range of neutral drugs in oral fluid.
Part 1: Advances in Field-Flow Fractionation: Supporting Development of Novel Nanomedicines
· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry
Part 2: Advances in Field-Flow Fractionation: Supporting Development of Novel Nanomedicines
Part 3: Advances in Field-Flow Fractionation: Supporting Development of Novel Nanomedicines
Ultrapure Water for HPLC Analysis
This application note presents the role of ultrapure water in HPLC analysis.
PFASs in Drinking Water Using Solid-Phase Extraction
This application note outlines a simple SPE procedure for the extraction of 26 diverse per- and polyfluoroalkyl substances (PFASs) in drinking water.
In-Well Hydrolysis Using UCT’s Refine™ Ultra-Filtration Technology
3-MCPD and Glycidol in Edible Oils
Automated GC/MS determination of 3-MCPD and glycidol in edible oils. Evaporation step helps reach required LODs with standard MSD and removes excess derivatization reagent for improved stability.
Utilizing Automated SPE to Improve the Recovery of Semivolatile Compounds in Compliance with EPA Method 8270
In a Pickle with Pesticides Sample Prep?
What you will learn: - Automated extraction method achieves higher recoveries - Steps involved in QuEChERs vs. EDGE method