The Column-11-20-2014

The Column

Profiling Alzheimer's Disease Biomarkers in Blood Serum

November 20, 2014

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Alzheimer's Disease (AD) is one of the most common neurodenerative disorders worldwide. It is a progressive disorder characterized by gradual loss of mental ability associated with the death of brain cells, and is diagnosed using a combination of physical, neurological, and laboratory tests. Although there are no curative treatments available, early treatment can reduce the rate of the disease progression. Scientists from the University of Huelva and the Neurological Service from the Hospital Juan Ramon Jim?nez in Spain, began collaborating four years ago to develop new strategies to identify biomarkers that could be used to speed up diagnosis of the disease. In a new study published in the journal Electrophoresis, the team present a metabolomics approach based on ultrafiltration followed by capillary electrophoresis coupled with mass spectrometry (CE–ESI–MS) for the fingerprinting of polar metabolites in blood serum.

The Development of Bioanalytical Methods for Pharmaceutical and Clinical Research

November 20, 2014

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The production of new drugs continues to increase, placing pressure on analytical scientists to develop new bioanalytical methods to characterize and ensure quality control and safety. Bethany Degg of The Column spoke to Lucie Novakova of Charles University in Prague, Czech Republic, about the development, optimization, and challenges of bioanalytical methods as well as future emerging research areas.

Trace-Level Quantitation of Tear Gas Lachrymators in Complex Matrices

November 20, 2014

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GC?GC–TOF-MS is used in forensic analysis for the analysis of tear gas lachrymators. In this article the analysis of a lachrymator standard is shown first, followed by the detection of capsaicin and dihydrocapsaicin at trace levels in a complex extract from contaminated clothing.

Monitoring Plastic Exposure in Seabirds

November 20, 2014

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Researchers from CSIRO Oceans and Atmosphere Flagship in Hobart, Australia, have published a new approach to monitoring plastic exposure in live birds. Featured in the journal Methods in Ecology and Evolution, the study describes the sampling of preen oil collected from seabirds using a simple swabbing method for gas chromatography coupled to mass spectrometry (GC–MS) analysis.1

Vol 10 No 21 The Column November 20, 2014 North American PDF

November 20, 2014

Issue PDF

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Click the title above to open The Column November 20, 2014 North American issue, Volume 10, Number 21, in an interactive PDF format.

Vol 10 No 21 The Column November 20, 2014 Europe and Asia PDF

November 20, 2014

Issue PDF

10

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Click the title above to open The Column November 20, 2014 Europe & Asia issue, Volume 10, Number 21, in an interactive PDF format.