April 16th 2024
In this edition of "Inside the Laboratory," John A. McLean, the dean of graduate education and research at the College of Arts & Science of Vanderbilt University, discusses his laboratory's recent work regarding ion mobility-mass spectrometry (IM-MS) and how it can be applied in various fields.
Quantitative Metrics to Properly Describe Solute Elution in Size-Exclusion Chromatography
February 16th 2024The purpose of this short tutorial article is to review the terms and official nomenclatures for size-exclusion separations and to provide some guidance and recommendations for practicing chromatographers. The interconversion between the different metrics is explained and some examples are presented.
The LCGC Blog: Are You Sick of Hearing About ChatGPT?
August 15th 2023Are you interested by ChatGPT's vast potential? Or are you getting tired of reading or hearing about ChatGPT? If the latter, this blog post might give you some tips and tricks on taking advantage of ChatGPT while avoiding its application beyond its intended scope.
How Much Data is Too Much? An Analysis of the Pros and Cons of High-Resolution Mass Spectral Data
August 1st 2023HRMS is widely used in chromatography for analyzing complex mixtures. However, chromatographers should take note of the exponentially larger data set that HRMS provides before deciding whether to use the technique for the analysis they are conducting.
Adjustable Polyacrylamide Stationary Phases Enhance Separation Performance in Liquid Chromatography
June 12th 2023Adjustable polyacrylamide stationary phases developed by researchers enhance separation performance in liquid chromatography, according to a recent publication. The study demonstrates the synthesis of vinyl modified silica and the successful preparation of polyacrylamide modified silica (PAM-SIL) stationary phases, allowing for fine control of separation performance.
Advances in Peak Width Analysis for Liquid Chromatography Techniques
May 18th 2023A researcher has derived an expression for peak width in liquid chromatography with exponential retention and linear program preceded by an isocratic hold, providing valuable insights for enhancing chromatographic separations.
The LCGC Blog: Working with Data Scientists to Improve Online Chemical Extraction and Analysis
September 7th 2022This instalment of the LCGC Blog investigates fundamental relationships between the structures of molecules and their interaction with different materials, in the context of online supercritical fluid extraction–supercritical fluid chromatography (SFE–SFC).