Application Notes

Articles

Learn how light scattering characterizes multiple biophysical attributes of different vaccine modalities in support of discovery, development, manufacture, and QC.
 


Characterizing Vaccines with Light Scattering

Comprehensive physicochemical characterization of biopolymers is accomplished by adding multi-angle light scattering and differential viscometry to standard SEC.


Analysis of Hyaluronic Acid by SEC-MALS-IV

Branching impacts polymer properties such as rheology and stiffness. This note explains the analysis of branching ratio versus molar mass, accomplished by SEC-MALS(-IV).

Polymer Branching Analysis by SEC-MALS-IV

How do bioinert and biocompatible liquid chromatography (LC) systems and columns improve separations of biomolecules? How do I know when these systems are required for my separation?

Troubleshooting LC Separations of Biomolecules, Part 1: Background, and the Meaning of Inertness

Analysis of Oligonucleotides by SEC

This note demonstrates the ability of a TSKgel® UP-SW2000 SEC column to discriminate oligonucleotides differing by one base in length.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

Quantifying CQAs of gene therapy vectors

In this note, the molecular weight averages and molecular weight distributions of two hydroxyethyl starch (HES) samples were successfully demonstrated.

Application Notes: Size-Exclusion Chromatography (SEC)