Application Notes: Size-Exclusion Chromatography (SEC)

GPC/SEC-Viscometry for Structural Analysis

August 28, 2023

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GPC/SEC-viscometry enables measurement of true molar masses for carrageenan and detects subtle differences between samples with similar molar mass distributions.

GPC/SEC-MALLS Analysis of Hyaluronic Acid (Aug 2023)

August 28, 2023

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GPC/SEC-MALLS analysis of hyaluronic acid obtains absolute molar mass while conventional GPC/SEC with concentration detectors only provides apparent molar masses.

Light Scattering and Size Exclusion Chromatography

August 28, 2023

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Discover how SEC can be used in biopolymer applications including bioconjugates, proteins, mAbs, mRNA1, viruses, extracellular vesicles, and liposomal nanoparticles.

Towards Greener GPC/SEC

August 28, 2023

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This paper discusses sustainable solutions for size separation of macromolecules that align with the 12 principles of green chemistry.

GPC/SEC Applications - Polymers, Biopolymers, Proteins

August 28, 2023

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Tips & Tricks designed to support GPC/SEC users in their daily work, providing comprehensive overviews on different aspects of this powerful technique.

Saccharide and Polysaccharide Analysis (Aug 2023)

August 28, 2023

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Robust, reliable GPC/SEC analysis of saccharides and polysaccharides can occur with very high resolution using Agilent SUPREMA columns with 3 and 5 µm particles.

PEGylated Antibody Fragment Analysis with SEC-MALS

June 26, 2023

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Pore Size Selection for SEC of Oligonucleotides (June 2023)

June 20, 2023

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Columns of the YMC-Pack Diol SEC series (120–300 Å), which have distinct pore sizes, were tested for their ability to separate DNA of various lengths (10–300mer).

Sensitive Quantification of AAVs/AAV Impurities

June 13, 2023

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Determine down to 8x10^9 AAV capsids and separate impurities of AAV samples by separation using a mixed-bed SEC column & highly sensitive MALS detection.

SEC-MALS Characterization of a Drug-delivery Polymer

November 21, 2022

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Learn the importance of light scattering detection to determine the true molecular weight distribution of a poly(glutamic acid)-based copolymer for drug-delivery.