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Superficially porous particle (SPP) column technology is leveraged to optimize high-throughput HPLC methods for small-molecule drug discovery, resulting in improved efficiency and reduced runtime.

Enhancing High-Throughput HPLC Methods for Small-Molecule Drug Discovery Using Superficially Porous Particle Technology

An analytical team has successfully developed a novel strategy for the separation of sanshools from Zanthoxylum bungeanum oleoresin using countercurrent chromatography, providing valuable insights for the separation of compounds with similar chemical properties.

Researchers Develop Innovative Strategy for Countercurrent Chromatography Separation of Sanshools From Zanthoxylum bungeanum Oleoresin

Researchers in Iran utilize graphene oxide aerogels to significantly improve the extraction and analysis of risperidone from plasma samples, offering enhanced accuracy and efficiency in pharmaceutical analysis.

Enhancing Risperidone Analysis: Graphene Oxide Aerogels Facilitate Efficient Extraction from Plasma Samples for HPLC-UV Analysis

A new publication introduces a groundbreaking automated system for high-throughput mass spectrometry analysis, reshaping the future of biotherapeutic characterization.

Revolutionizing Biotherapeutic Analysis: The Automated Future of Mass Spectrometry

Metabolic Perturbation Score-Based Mass Spectrometry Imaging (MPS-MSI) offers spatially resolved insights into the functional metabolic response, facilitating a deeper understanding of disease progression and drug action, and paving the way for improved therapeutic strategies and targeted interventions.

Metabolic Perturbation Score-Based Mass Spectrometry Imaging: Illuminating the Spatial Dynamics of Functional Metabolism

Scientists have developed an automatic and highly efficient method to authenticate single herbal powders using microscopy-guided in situ auto-sampling combined with matrix-assisted laser desorption–ionization mass spectrometry (MALDI–MS).

New Tool for Authenticating Single Herbal Powders

A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.

Study Finds That Using Seven Points Across a Peak Is Sufficient for Accurate LC–MS/MS Quantitation

A new article discusses the benefits and drawbacks of RPLC and RPLC×RPLC chromatography techniques. It provides recommendations for selecting the best approach for analyzing small pharmaceuticals and peptides.

Study Compares RPLC and RPLC × RPLC For Improved Chromatography

Scientists have developed a magnetic ionic liquid hypercrosslinked polymer composite for use in magnetic solid-phase extraction (MSPE) of non-steroidal anti-inflammatory drugs (NSAIDs), which was coupled with high-performance liquid chromatography (HPLC) for the detection of trace amounts of NSAIDs in water and urine samples.

Magnetic Solid-Phase Extraction (MSPE) with HPLC Method Developed for NSAID Analysis

New article reviews the progress in suppression techniques for ion chromatography from 1981 to 2022, with an emphasis on the last ten years, and discusses the current challenges and future prospects regarding suppressors.

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