Topic

Articles

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Separation Science: The State of the Art: On the Contemporary Analysis of Protein Biopharmaceuticals

Webcasts

Webinar Dates/Times:

Wednesday, December 14th, 2022 at 10am EST|3pm GMT
Wednesday, December 14th, 2022 at 2pm EST|11am PST
Thursday, December 15th, 2022 at 12pm JST|11am CST


Analysis & Purification of Oligonucleotides: Method Development Optimization from Characterization to Purification

Webinar Date/Time: Friday, December 9th, 2022 at 11am EST|8am PST|4pm GMT|5pm CET

Novel Oligonucleotide Sample Clean-up and Method Optimizations (rebroadcast)

What is the right number of replicates in biopharmaceutical analysis?
Does the answer depend on the type of analysis?


On Replication in Biopharmaceutical Analysis

Pepsin digestion and guanidine hydrochloride post-digestion can improve sequence coverage in antibody peptide mapping compared with trypsin digestion.

Overcoming Incomplete Peptide Mapping of Antibody Complementarity-Determining Regions with Alternate Digestion Workflows

In response to regulatory concerns, host cell protein (HCP) analysis is now often conducted using LC–MS/MS. Unlike ELISA, LC–MS/MS can positively identify and quantify specific HCPs and characterize the total amount of HCPs present.

Analytical Characterization of Host Cell Proteins (HCPs)

 received his PharmD from University of Rome “Sapienza” and his Ph.D from University of Geneva under the mentorship of Jean‑Luc Veuthey and Davy Guillarme. He is currently Postdoctoral Fellow in the Analytical Enabling Capabilities Group within MRL Analytical Research & Development Department, under the supervision of Erik L. Regalado.

To reach satisfactory results in terms of accurate retention time prediction, new in silico optimization approaches must be considered. 

Nonlinear Predictive Modelling Enables In Silico Optimization of Chromatographic Methods for Complex Stationary Phase‑Analyte Interactions

Sample preparation and analysis of pharmaceuticals in wastewater present unique challenges. Here, we describe those challenges.

Wastewater Surveillance of Pharmaceuticals and Genes: Challenges and Opportunities

Small metabolic molecules often are chiral and can play important roles in regulating a variety of biological functions, occasionally providing information about the presence and progression of disease.

Analysis of D-Amino Acids: Relevance in Human Disease

Headspace GC reveals that sonication can degrade common organic solvents.

Biopharmaceuticals and Protein Analysis | Topics