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© 2022 MJH Life Sciences and Chromatography Online. All rights reserved.
© 2022 MJH Life Sciences™ and Chromatography Online. All rights reserved.
June 09, 2022
An analytical method for the separation of oligonucleotides of different chain length by IEC using a bio-inert UHPLC system is presented.
June 01, 2022
An overview of mRNA-based vaccine production and a discussion on the methods that are currently in use to check the quality of these vaccines.
Recent assessments of four biosimilars illustrate how a combination of orthogonal, high-resolution tools is used to demonstrate analytical and functional biosimilarity.
Advances in sample preparation have enabled analysis of RNA modifications in single cells, paving the way to discovering new insights into the functions of these molecules.
May 06, 2022
The benefits of tandem LC–MS are revealed.
The Column interviewed Valentina D’Atri about her work to couple CEC to MS, and the challenges of analyzing complex biopharmaceuticals.
April 01, 2022
The articles presented here highlight important recent developments in biopharmaceutical analysis.
Multi-isocratic elution mode is a powerful chromatographic approach for characterizing minor isoforms of monoclonal antibodies.
Flow-through immobilized-enzyme reactors (IMERs) can streamline protein digestion for bottom- and middle-up LC–MS characterization while providing high accuracy and reproducibility.
Commercially available trypsin IMERs can digest proteins with high sequence coverage and robustness, facilitating online multidimensional LC–MS.