June 5th 2025
The latest edition of "Column Watch" features our annual review of new liquid chromatography columns and accessories, introduced at Pittcon and other events over the past 12 months.
Tips & Tricks: GPC/SEC Analysis of Aqueous Polymer Dispersions
August 8th 2024Polymer dispersions are used in numerous applications including paints, binders, and adhesives. These complex mixtures usually contain polymeric components that contribute significantly to their physical and chemical properties.
Quantitative Metrics to Properly Describe Solute Elution in Size-Exclusion Chromatography
February 16th 2024The purpose of this short tutorial article is to review the terms and official nomenclatures for size-exclusion separations and to provide some guidance and recommendations for practicing chromatographers. The interconversion between the different metrics is explained and some examples are presented.
Calibrating the Low Molar Mass Range in GPC/SEC Using Oligomer Peaks
February 15th 2024Reliable calibration curves in the low molar mass region can be obtained when using the elution volumes of all separated oligomers of low molar mass standards on high resolution columns. This article explains how to do this.
New Strategies for Oligonucleotide Aggregate Analysis
January 15th 2024Technological limitations have made it difficult for scientists to identify oligonucleotide aggregates. This can pose challenges when finding techniques to reliably analyze size variants for large nucleic acids and lipid nanoparticles (LNPs).