Application Notes: General

The KNAUER Sepapure oliGO column is a good alternative to the commonly used competitor column for oligonucleotide analysis.

This technical note demonstrates a sensitive method for the quantitation of pasireotide in human plasma using high-resolution accurate mass spectrometry. A lower limit of quantitation (LLOQ) of 0.05 ng/mL was achieved in extracted plasma samples.

Explore best practices for LC-MS analysis of oligonucleotides to get the best results possible, quickly and easily.

This technical note demonstrates a highly sensitive, robust and rapid workflow to quantify TL 13-112, a selective ALK degrader, and its inactive control, TL 13-110, in rat plasma using a high-end triple quadrupole mass spectrometer.

This webinar covers quantitative bioanalysis strategies to support mRNA drug development using LC-MS, including sample preparation, surrogate peptide selection, LC-MS method development, and verification/validation.

Discover how Arium® Comfort I UV system supports precise PFAS detection, reducing contaminants to sub-ppt levels while improving sustainability and cost efficiency.

Per- and Polyfluoroalkyl Substances (PFAS), a family of more than 4,700 chemical molecules, are known for their non-stick and waterproof properties. These versatile compounds find their application in a variety of industries, including cosmetics, textiles, and automobiles. PFAS exhibit remarkable resistance to degradation, which has led to their pervasive distribution in the environment and consequent human exposure. The effects of such exposure are far-reaching, including adverse effects on fertility, developmental abnormalities, cholesterol levels, immune function, and an increased risk of certain cancers. In addition to their toxicological effects, PFAS have become a global concern as regulators and researchers strive to understand the extent of their impact and develop effective methods for detection and mitigation. This collection of articles brings together research on the contamination and effects of PFAS in air, soil, and water, shedding light on the complex challenges posed by these persistent substances in our environment. Overall, this collection of articles seeks to advance researchers' knowledge of the dynamics, effects, and detection of PFAS.

A novel HIC column featuring innovative particle technology is benchmarked for separation of high DAR species ADCs, against a reference column with conventional chemistry.

Cells beyond their sell-by date exhibit a higher probability to propagate damaged cellular components like DNA, which leads to disease. It is therefore necessary for the body to remove these old malfunctioning cells, which can be done with garlic. All of the active components of garlic are easily isolated using the 5 µm PRP-C18 HPLC column.

Capsaicin, the compound responsible for the burning sensation in chili peppers, has been researched for its potential therapeutic benefits, including reducing cholesterol and blood sugar levels, and exhibiting anti-inflammatory and analgesic properties. Hamilton's PRP-C18 reversed-phase HPLC column was used to isolate major capsaicinoids, with formic acid as the aqueous mobile phase, achieving good correlation with literature values at 10190 Scoville Heat Units. The Hamilton PRP-C18 column demonstrated excellent peak shape and can be easily regenerated, making it an indispensable tool for synthetic chemists.

In this study of an essential oil, we have developed an HPLC method for the separation of 6 well-known markers for the determination of purity of Ylang-Ylang oil.

Due to the short half-life of the 18F radionuclide, radiotracers are preferably produced locally or transported over short distances, leading to local production. On-site quality control is critical before clinical use. See how the RCX-10 enables reliable analysis for radiotracers.

This study analyzed BPA and its derivatives leaching from BPA-free polycarbonate water bottles using HPLC with UV detection and found that these bottles still contain bisphenol derivatives that can leach into water or ethanol. Leaching increased with temperature and was more pronounced with ethanol than hot water. Repeated washing with either hot water or 40% ethanol effectively removed leachable bisphenols without damaging the bottles.

Learn how biomarkers, Organ on a Chip Models models and PBPK tools improve toxicity and DDI prediction, cut false positives, and support clearer, ICH M12-aligned decision-making.

Metrohm’s MiPCT-ME technique enables trace-level determination of anions in N-methylpyrrolidone, ensuring lithium-ion battery quality, stability, and safety.

The GERSTEL TVOC Wizard streamlines and accelerates VDA 278 material emissions data processing by combining automated workflows, advanced deconvolution, and integrated NIST-based compound identification. Complex chromatograms—often dominated by co-eluting peaks—are reliably resolved using MCR-AR Targeted algorithms, while retention indices and customizable process steps ensure standard-compliant, high-quality results. The software eliminates error-prone manual transfers, increases data consistency, and delivers clear, customizable VOC and FOG reports aligned with industry requirements.

This method showcases a precise, automated workflow for determining methylene chloride in indoor air using thermal desorption GC-MS and GERSTEL’s ISDP module. Automated gaseous internal standard addition ensures highly reproducible tube spiking, while optimized TD and GC-MS parameters provide sensitive and stable quantification—well below OSHA exposure limits. The approach enables accurate baseline monitoring in laboratories, offices, and industrial environments where regulatory compliance and worker protection are essential.

The GERSTEL TVOC Wizard streamlines and accelerates VDA 278 material emissions data processing by combining automated workflows, advanced deconvolution, and integrated NIST-based compound identification. Complex chromatograms—often dominated by co-eluting peaks—are reliably resolved using MCR-AR Targeted algorithms, while retention indices and customizable process steps ensure standard-compliant, high-quality results. The software eliminates error-prone manual transfers, increases data consistency, and delivers clear, customizable VOC and FOG reports aligned with industry requirements.

Discover how the PET Recycling Team is setting new standards in recycled material performance using the GC 2400 systems to transform quality control process and accelerate your sustainability goals

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

The study was done to validate method performance for the expanded list of PFAS compounds required by the State of California Water Resources Board for wastewater.

Dynamic Focusing enables cryogen-free trapping of VOCs and VVOCs from ambient air, delivering method-compliant sensitivity and precision for TO-17 and ISO 16000-6.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using GCMS 2400, ensuring compliance, sensitivity, and resolution.

Discover a robust GC headspace method for accurate, low-carryover detection of residual NMP in Li-ion batteries using the GC 2400 and HS 2400M systems.