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Application Notes: General

Nitrosamines & Genotoxic Impurities in Pharmaceutical Development and Manufacturing

Nitrosamines have become one of the defining challenges in pharmaceutical analysis, and this eBook from LCGC International captures the field at a pivotal moment. Inside, a roundtable of leading voices examines a discipline progressing rapidly, yet still grappling with analytical, toxicological, and regulatory uncertainties, a survey maps the latest chromatographic and risk-modeling research, and a featured study reveals how NDSRIs can even form after a drug is swallowed, under simulated gastric conditions. Add in a practical guide to formation pathways and mitigation strategies, and you get a comprehensive look at where nitrosamine detection, regulation, and risk management stand today. Whether you're developing methods for trace-level impurity detection or want to understand where the regulatory and scientific landscape is headed, this eBook delivers the research and expert insight to keep you ahead of a genuinely moving target.

Understanding and Applying USP Chapter 621 for Generic Pharmaceutical Applications

ByPhenomenex, Inc.

This executive summary explores how revisions to USP <621> have introduced greater flexibility in chromatographic method adjustments while reinforcing system suitability as the definitive standard for method acceptance. Heiko Behr, senior business development manager at Phenomenex, walks through key principles governing column substitution, flow rate scaling, mobile phase control, and dwell volume management during method transfer. A practical Nifedipine case study demonstrates how these allowances can be applied to reduce run times tenfold without compromising monograph-defined selectivity or compliance.

Current Trends in Mass Spectrometry June 2026

This issue of Current Trends in Mass Spectrometry brings together five perspectives on where mass spectrometry is heading next — from smarter polymer characterization and high-throughput food flavour analysis, to tackling food fraud, understanding ionic liquids, and expanding ion mobility techniques beyond proteomics. Whether you work in pharma, food science, environmental monitoring, or materials research, there's something here to inform and inspire.

Analytical Solutions for PFAS Testing - Routine to Discovery Analysis in Environmental Samples and Consumer Products

ByShimadzu Corporation

Sponsored Content

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of over 4000 organic fluorinated compounds, which have been widely used in industry since the 1950s. Due to their widespread presence and potential health risks, accurate PFAS analysis is essential to monitor contamination, ensure regulatory compliance, and protect human health and the environment. In this eBook, we explore our range of chromatography and mass spectrometry (MS) solutions for detecting very low levels of PFAS in matrices such as drinking water, wastewater, ambient air, foodstuffs, and consumer products. Plus, learn through a series of case studies how our LC-MS/MS systems and other analytical instruments (GCMS, CIC, QTOF…) meet and often exceed performance criteria included in EPA and AOAC methods for PFAS analysis – generating accurate results with fast turnaround times that enhance lab productivity.

Food Authenticity and Fraud Detection: A Separation Science Perspective

Advances in analytical methods continue to enhance food authenticity testing, emphasizing untargeted fingerprinting, high-resolution mass spectrometry, and rapid portable tools. Techniques like DART-HRMS and LC–MS enable detection of adulteration at low levels, with robust validation and harmonization critical for legal and industrial confidence. Integrating chemometrics and developing standardized databases are key to addressing evolving food fraud challenges.

Choosing Your Carrier Gas: Why BIP® Helium Is the Right Choice

ByAir Products

This article explains why carrier gas selection remains critical for modern gas chromatography (GC) and GC–MS workflows. The discussion explores the ongoing relevance of helium, the performance advantages of BIP® Helium for high-sensitivity applications, and how laboratories can balance cost, efficiency, and sustainability through informed carrier gas strategies.

Controlling Background PFAS Across Trace-Level LC-MS/MS Analytical Workflows

ByPhenomenex, Inc.

As regulatory mandates push PFAS detection limits toward single-digit PPT levels, the pervasive threat of background contamination from solvents and instrument components has emerged as a defining challenge for modern laboratories. Proper data defensibility requires a rigorous, end-to-end mitigation strategy that prioritizes the replacement of fluoropolymer materials with inert alternatives as well as the implementation of delay columns to isolate system-derived interference. Ultimately, adopting a proactive approach to workflow integrity, through the use of certified consumables and specialized tools, is essential for laboratories to stay ahead of tightening environmental standards and expanding target lists.

My PFAS Testing Cheat Sheet

ByAgilent Technologies, Inc.

Explore practical strategies for reducing PFAS contamination risks in food testing workflows with guidance on troubleshooting, blank management, chromatography optimization, and contamination control. This quick-reference resource highlights common sources of false positives and false negatives while outlining best practices for achieving reliable low-ppt PFAS analysis across complex food matrices.