Application Notes: Medical/Biological
MALDI Guided SpatialOMx® Uncovers Proteomic Profiles in Tumor Subpopulations of Breast Cancer
September 1st 2020The timsTOF fleX system bridges a current gap by providing MALDI Imaging and in-depth proteomics analysis in just one instrument. The instrument offers all benefits of a timsTOF Pro for time-efficient and sensitive proteomics, combined with a high-resolution MALDI source and stage. Using PASEF technology, it is possible to retrieve high protein ID rates with small sample amounts. Here we present the new SpatialOMx® workflow to identify distinct proteomic profiles for different tumor subpopulations in breast cancer as an example for this powerful approach.
Restek - Analysis of Fentanyl and Its Analogues in Human Urine by LC–MS/MS
June 1st 2020Abuse of synthetic opioid prescription painkillers such as fentanyl, along with a rapidly growing list of illicit analogues, is a significant public health problem. In this study, we developed a simple dilute-and-shoot method that provides a fast 3.5-min analysis of fentanyl and related compounds (norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl, carfentanil, remifentanil, and sufentanil) in human urine by liquid chromatography–tandem mass spectrometry (LC–MS/ MS) using a Raptor Biphenyl column.