Characterization of TSKgel FcR-IIIA-NPR HPLC Column by Top Down Mass Spectrometry
February 01, 2019
The purpose of this study is to demonstrate the use of mass spectrometry to characterize the elution profile of a typical IgG1 molecule separation on a TSKgel FcR-IIIA-NPR column, and verify the observations that certain glycan structures impart higher activity to the monoclonal antibody, especially as it relates to the presence of terminal galactose sugars.