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A panel discussion on the latest advances and future developments in sample preparation.

Trends and Developments in Sample Preparation

Tony Taylor is Group Technical Director of Crawford Scientific Group and CHROMacademy. His background is in pharmaceutical R&D and polymer chemistry, but he has spent the past 20 years in training and consulting, working with Crawford Scientific Group clients to ensure they attain the very best analytical science possible. He has trained and consulted with thousands of analytical chemists globally and is passionate about professional development in separation science, developing CHROMacademy as a means to provide high-quality online education to analytical chemists. His current research interests include HPLC column selectivity codification, advanced automated sample preparation, and LCâMS and GCâMS for materials characterization, especially in the field of extractables and leachables analysis.

Which key efficiency techniques can maximize your analytical  goals? This instalment of the LCGC Blog begins by describing the principles and optimization of liquid-liquid extraction (LLE).

Inexpensive, Quick, and Selective: Seeking the Holy Grail of Sample Extraction

It is important to develop analytical methods to detect  crude MCHM components in environmental water samples. This article describes two microextractive methods based on solid-phase microextraction (SPME) in fibre format and thin film microextraction (TFME) that were developed and validated for 4-MCHM and other constituents of crude MCHM.

Exploring the Efficiency of Various Extraction Approaches for Determination of Crude MCHM Constituents in Environmental Samples

This article reviews how nanomaterials are being used in a variety of sample preparation techniques, such as dispersive solid-phase extraction (dSPE), solid-phase microextraction (SPME), stir-bar sorptive extraction (SBSE), and matrix solid-phase dispersion (MSPD).

Nanomaterials Have Come to Stay:  An Overview of their Use as Sorbents in Sample Preparation

The analysis of contaminants found in environmental waters and originating from personal care products using metalorganic frameworks (MOFs) combined with liquid chromatography (LC) is described. This work expands the use of MOFs from gas chromatography to LC and also meets the requirements of green analytical chemistry.

Dispersive Miniaturized Solid‑Phase Extraction Using the CIM‑81 Metal‑Organic Framework and Gas Chromatography–Mass Spectrometry to Determine Personal Care Products in Waters

A simple method for the analysis of leachables using solid-phase microextraction (SPME) and comprehensive two-dimensional gas chromatography, coupled to mass spectrometry (GCxGC–MS). This fully automated method bypasses the use of solvents and excessive sample handling. Four potential leachables were tentatively identified.


Solid-Phase Microextraction Combined with Flow-Modulated Comprehensive Two-Dimensional GC for Screening Leachables in the Pharmaceutical Industry

Douglas E. Raynie explores formal and informal training opportunities that may be available to educate all chemists in the fundamentals of necessary laboratory sample preparation skills.

The (Mis)education of an Analyst

Oliver Napoleon Hill (1883– 1970) was an American self-help author once described as ”the most famous conman you’ve probably never heard of” (1 ). Conman maybe, but there is a quote of his that I believe to be particularly true when considering sample preparation for chromatography techniques; ”The one who tries to get something for nothing generally winds up getting nothing for something.”

The LCGC Blog: Inexpensive, Quick, and Selective: Seeking the Holy Grail of Sample Extraction

In electromembrane extraction (EME), the target analyte is extracted from an aqueous sample across a supported liquid membrane (SLM) and analyzed using LC. Through the study presented here, we demonstrate the principles of the technique and test its performance.

Electromembrane Extraction with Vials of Conducting Polymer

Kevin A. Schug is a Full Professor and Shimadzu Distinguished Professor of Analytical Chemistry in the Department of Chemistry & Biochemistry at The University of Texas (UT) at Arlington. He joined the faculty at UT Arlington in 2005 after completing a Ph.D. in Chemistry at Virginia Tech under the direction of Prof. Harold M. McNair and a post-doctoral fellowship at the University of Vienna under Prof. Wolfgang Lindner. Research in the Schug group spans fundamental and applied areas of separation science and mass spectrometry. Schug was named the LCGC Emerging Leader in Chromatography in 2009, and most recently has been named the 2012 American Chemical Society Division of Analytical Chemistry Young Investigator in Separation Science awardee.

When working with complex samples, we need effective approaches to deal with matrix interferences. Here, we outline methods of sample preparation, on-line sample treatment, and instrument tools that can help. We also provide examples of applications and guidance for how to evaluate the best option for your complex sample.

Sample Preparation | Topics