Application Notes: Biopharmaceuticals

This application note shows a micro-flow LC–MS method developed on the Thermo Scientific Vanquish Neo UHPLC system is suitable for high-throughput proteomic analyses of large sample cohorts.

This application note shows a micro-flow LC–MS method developed on the Thermo Scientific Vanquish Neo UHPLC system is suitable for high-throughput proteomic analyses of large sample cohorts.

This application note reveals the Thermo Scientific Vanquish Neo UHPLC system offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.

This application note reveals the Thermo Scientific Vanquish Neo UHPLC system offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.

This application note will illustrate how a new integrated pump controller is giving users automated control of pump operations in critical biopharma applications.

This application note reveals the Vanquish Neo offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.

This application note shows a micro-flow LC–MS method developed on the Vanquish Neo UHPLC is suitable for high-throughput proteomic analyses of large sample cohorts.

The development of comprehensive liquid chromatography–high resolution accurate mass workflows for confident identification and mapping of oligonucleotides.

This white paper will illustrate how integrated pump controllers optimize pump performance by automatically controlling flow or pressure.

This goal of this note is identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC–MS in a top-down experiment.

This white paper will illustrate how integrated pump controllers optimize pump performance by automatically controlling flow or pressure.

This white paper will illustrate how integrated pump controllers optimize pump performance by automatically controlling flow or pressure.

This white paper will illustrate how integrated pump controllers optimize pump performance by automatically controlling flow or pressure.

With a new electrochemical cell, complete reduction of inter- and intra-disulfide bonds in mAbs is achieved with superior sequence coverage.

Learn the advantages of HILIC to measure and monitor glycosylation, deamidation, and oxidation, which are critical for the function and form of proteins and peptides.

Multi-angle light scattering couples inline with ion exchange chromatography to estimate the aggregate content of protein fractions without additional offline assays.

This tech note demonstrates the benefits of single quadrupole mass detection for small protein analysis.

AAV characterization and stability screening are achieved with multi-angle light scattering coupled to separation methods and high-throughput dynamic light scattering.

This application note investigates the use of YMC BioPro SF for high-resolution charge variant analysis of four therapeutic mAb products.

The dial-a-mix method with a quaternary pump HPLC quickly screens different method conditions when developing ion-exchange methods for charge variant analysis of mAbs.

This application note describes the benefits of using YMC-Triart PEEK-lined columns for separations involving coordination compounds.

This application note investigates using YMC-Triart C18 for analysis of 11 common cannabinoid compounds.

This application note details real-life client data obtained for insulin purification and manufacturing using YMC’s new YMC-Triart Prep Bio200 C8 material.

This application note details the use of light scattering detection coupled with SEC analysis for characterization of proteins and antibodies.

Learn how AAVs are characterized for critical quality attributes and stability by multi-angle and dynamic light scattering.

The unique design of the 50 cm μPAC™ GEN2 nanoLC column provides superior performance over state-of-the-art packed bed columns, achieving peak capacities of over 1000.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio. 

AEX using a TSKgel® DNA-NPR column offers a rapid method for discriminating between covalently closed circular, open circular, and linear forms of plasmid DNA.