Application Notes: GC

GC-FID enables accurate benzene analysis in USP Carbomer 940, meeting system suitability and supporting compliant pharmaceutical quality control workflows.

Analyze residual solvents in flexible food packaging with GC 2400 and HS 2400 M, delivering accurate, compliant results and no carryover.

Effluent wastewater testing is essential for protecting human health and the environment, and EPA Method 624.1 is a widely used approach for monitoring volatile organic compounds (VOCs) in water. This application note demonstrates how the combination of the Teledyne LABS Tekmar Lumin Purge & Trap (P&T) concentrator, AQUATek LVA autosampler, and PerkinElmer GCMS 2400 platform delivers accurate, reliable, and highly sensitive VOC analysis while effectively managing water vapor transfer that can compromise GC/MS performance.

Dibenzyl disulfide (DBDS) is a corrosive sulfur compound that can accelerate copper sulfide formation in transformers, increasing the risk of insulation damage and equipment failure. Routine monitoring of DBDS is therefore critical for transformer health, regulatory compliance, and preventive maintenance. This application note demonstrates how the PerkinElmer GC 2400 System with Electron Capture Detection (ECD) provides a sensitive, reliable, and cost-effective approach for DBDS analysis in transformer oils, delivering excellent linearity, precision, and freedom from carryover in accordance with IEC 62697 guidelines.

This note applies the EPA 1633 workflow to fish and animal tissues, enabling sensitive, low‑level PFAS detection using automated SPE and LC/MS/MS. The dual‑layer SPE design improves efficiency and recovery, meeting all EPA performance criteria across complex tissue matrices.

In food safety testing, instrument reliability under real-world conditions is the true test of performance. This technical note showcases the durability and consistency of the PerkinElmer QSight® 500 LC/MS/MS system through an intensive robustness study, analyzing high-matrix food samples with minimal cleanup and no loss in sensitivity. Using a simplified QuEChERS extraction (no SPE), the system successfully analyzed PFAS analytes across complex matrices like salmon, avocado, pet food, and spices. The results highlight not only long-term stability but also the power of StayClean™ technology to reduce downtime and keep throughput high.

This application note describes a fast and robust LC‑MS/MS method for honey authenticity testing by targeted quantification of 3‑methoxytyramine, a specific marker for beet‑sugar feeding. Using the QSight® 500 LC‑MS/MS with EDIT‑ESI and a simplified Blend‑and‑Inject workflow, the method eliminates SPE and isotopically labeled internal standards while delivering high sensitivity, excellent reproducibility, and high throughput for routine commercial and regulatory honey testing.

This application note presents a simplified Blend‑and‑Inject LC‑MS/MS method for the quantification of 25 PFAS compounds in animal‑derived food matrices using the QSight® 500 LC‑MS/MS system. By eliminating SPE and leveraging matrix‑matched calibration, isotopically labeled standards, and a PFAS delay column, the method achieves EU‑compliant sensitivity and robust performance in complex tissues, enabling high‑throughput and reliable PFAS monitoring for food safety compliance.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

HS-GC-FID enables compliant residual solvent analysis per USP 467, delivering accurate quantitation, full separation, and improved productivity in pharma labs.

A robust HS-GC-FID workflow on the PerkinElmer GC system enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

GC-FID enables accurate benzene analysis in USP Carbomer 940, meeting system suitability and supporting compliant pharmaceutical quality control workflows.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

For sulfur compounds in the sub-ppmv to ppbv and lower concentrations, dynamically generated gas standards prevent the need for storing reactive and unstable components

Actively recording calibration gas data... creates unique advantages over traditional cylinder gas calibration.

VUV’s diesel fuel application enables rapid, automated measurement of saturates, aromatics, PAHs, and FAMEs in a single GC–VUV run using ASTM D8368. This direct-injection method requires no sample prep or calibration curves, delivers class-based spectral validation, and provides accurate results in under 30 minutes

VUV’s GC–VUV platform with ASTM D8267 enables rapid, automated measurement of total, mono-, and diaromatic content in jet fuel with superior precision and reproducibility compared to FIA and HPLC. This direct-injection method requires no sample prep or calibration curves, delivers results in 14 minutes, and significantly lowers cost per analysis

VUV’s GC–VUV platform with ASTM D8071 enables fast, automated PIONA and multi-parameter gasoline analysis in a single run. It delivers superior precision and reproducibility compared to traditional methods, requires no sample prep or calibration curves, and consolidates multiple regulatory tests into one cost-efficient workflow

Demonstrate reliable measurement of water at trace levels and beyond in acetonitrile using gas chromatography (GC) combined with the LUMA Multi-Channel Vacuum Ultraviolet (VUV) Absorbance detector. Additionally, we will demonstrate the ability of LUMA to detect water and multiple solvents in a single analysis.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent in plastic with accuracy and sensitivity, providing reliable and reproducible runs for high throughput laboratories.

Discover how the PerkinElmer GC 2400™ Platform provides fast analysis and high reproducibility.

Read how the integrated HS-GC workflow allows a continuous optimization of the pneumatic values for ultimate precision in GC retention time.

Discover an optimized GC/MS approach for SVOC in complex matrices.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover the GC 2400™ Platform for analytical precision and robustness for fuel alcohol analysis over a wide range of sample concentrations.

Read about compliant analysis for the determination of ethanol and methanol content in fuels.