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High-performance liquid chromatography (HPLC) reveals how melanoma vesicles suppress immunity, informing immunotherapy response tracking.

In this month's LCGC Blog, Caitlin Cain from the University of Virginia examines whether technological advances in chromatography—particularly the adoption of big data, artificial intelligence (AI), and machine learning (ML)—are reducing the emphasis on the fundamental chromatographic theory that is key to understanding the technique.

In the third of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses the a need for dedicated LT-ZIC-HILIC retention time library for metabolic research.

Jonathan Maurer from the University of Geneva, Switzerland describes using HILIC for oligonucleotide analysis in practice and the role of HILIC for other biopharmaceutical applications.

Jonathan Maurer from the University of Geneva, Switzerland describes some of the challenges and misconceptions surrounding hydrophilic interaction chromatography (HILIC) and oligonucleotide analysis.

Gas chromatography (GC) measures volatile sulfur compounds (VSCs) in breath samples to assess remote halitosis diagnosis reliability.

Ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) identifies phenolic compounds driving honey's bioactive properties

In the second of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses the biggest bottlenecks in untargeted metabolomics right now.

Wallman argues proteomics is moving from niche tool to high-throughput platform core, with the greatest untapped potential in covalent drug programs and targeted protein degradation.

Gas chromatography-mass spectrometry (GC-MS) reveals harmful cooking emissions in New York City restaurant kitchens, raising worker health concerns.

Liquid chromatography-mass spectrometry (LC-MS) reveals how flunitrazepam degrades post-mortem, aiding forensic overdose confirmation.

In the first of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses her ASMS 2026 presentation, Low-Temperature HILIC Provides Enhanced Separations and Stability for LC–MS-Based Metabolomics.

Wallman explains that PeptDeepKontext is designed to generalize without lab-specific calibration, though highly unusual setups may still benefit from additional fine-tuning in the future.