Quantifying Terpenes in Hydrodistilled Cannabis sativa Essential Oil with GC-MS
A recent study conducted at the University of Georgia, (Athens, Georgia) presented a validated method for quantifying 18 terpenes in Cannabis sativa essential oil, extracted via hydrodistillation. The method, utilizing gas chromatography–mass spectrometry (GC–MS) with selected ion monitoring (SIM), includes using internal standards (n-tridecane and octadecane) for accurate analysis, with key validation parameters—such as specificity, accuracy, precision, and detection limits—thoroughly assessed. LCGC International spoke to Noelle Joy of the University of Georgia, corresponding author of this paper discussing the method, about its creation and benefits it offers the analytical community.
Understanding FDA Recommendations for N-Nitrosamine Impurity Levels
April 17th 2025We spoke with Josh Hoerner, general manager of Purisys, which specializes in a small volume custom synthesis and specialized controlled substance manufacturing, to gain his perspective on FDA’s recommendations for acceptable intake limits for N-nitrosamine impurities.
University of Rouen-Normandy Scientists Explore Eco-Friendly Sampling Approach for GC-HRMS
April 17th 2025Root exudates—substances secreted by living plant roots—are challenging to sample, as they are typically extracted using artificial devices and can vary widely in both quantity and composition across plant species.
Determining the Serum Proteomic Profile in Migraine Patients with LC–MS
Researchers used liquid chromatography–mass spectrometry (LC–MS) in their proteomic analysis to compare the serum proteome of migraine patients with healthy controls and to identify differentially expressed proteins as potential migraine biomarkers.
Thermodynamic Insights into Organic Solvent Extraction for Chemical Analysis of Medical Devices
April 16th 2025A new study, published by a researcher from Chemical Characterization Solutions in Minnesota, explored a new approach for sample preparation for the chemical characterization of medical devices.
Sorbonne Researchers Develop Miniaturized GC Detector for VOC Analysis
April 16th 2025A team of scientists from the Paris university developed and optimized MAVERIC, a miniaturized and autonomous gas chromatography (GC) system coupled to a nano-gravimetric detector (NGD) based on a NEMS (nano-electromechanical-system) resonator.
Determining the Link Between Prenatal Cannabis Use and Symptoms of Depression Using LC–MS/MS
Researchers investigating the relationship between cannabis use during pregnancy and depressive symptoms—and whether continued use beyond the first trimester or higher levels of use were linked to increased symptoms—used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to confirm the presence of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in urine samples.