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This gas chromatography-quadrupole orbital trap high-resolution mass spectrometry (GC-Q-Orbitrap HRMS) method detects 215 pesticides in high-fat peanut matrices reliably.

Capillary liquid chromatography (CapLC) offers compelling advantages in sensitivity, solvent reduction, and compatibility with modern mass spectrometry, yet remains underutilized in routine analytical workflows. This article synthesizes expert discussions from a Pittcon 2026 networking session to examine why CapLC adoption has lagged despite decades of development. Key themes include educational gaps, instrumentation limitations, robustness concerns, detection challenges, and supply‑chain constraints. The discussion highlights areas where CapLC already delivers clear value—such as proteomics, oligonucleotide analysis, and high‑throughput screening—and outlines practical pathways for broader adoption through targeted applications, improved instrumentation, and redefined expectations of “routine” chromatography.

30% of GC–MS peak annotations and integrations have been observed to be inaccurate. Hans-Gerd Janssen highlights some of the most promising strategies to improve data reliability and reduce errors.

Hans-Gerd Jansses discusses problems associated with LC–MS peptide identification data with sensory perception and the identification of specific tastants for food analysis.

A non-targeted high-resolution mass spectrometry strategy was developed to detect PFAS in food beyond the limits of conventional targeted methods.A non-targeted high-resolution mass spectrometry strategy was developed to detect PFAS in food beyond the limits of conventional targeted methods. Using a single extract for both approaches, data prioritization and ion mobility mass spectrometry helped identify previously unsuspected PFAS, expanding analytical coverage for food safety monitoring.

Liquid chromatography-mass spectrometry (LC-MS) tracks gut bacteria activity before and after cognitive behavioral therapy treatment for social anxiety disorder.

Mass spectrometry–based techniques, including cross-linking and covalent labeling, were used to show how phosphorylation and oxidation alter alpha-synuclein structure, providing insight into how these modifications may influence aggregation and neurodegenerative disease. LCGC International spoke to Ian Webb, corresponding author of a paper that resulted from this research.

"GC Connections" column editor Nicholas Snow offers a basic GC maintenance tools and supplies overview.

Gas chromatography-mass spectrometry (GC-MS) headspace analysis identifies dimethyl disulfide as a microbial marker in spacecraft wastewater.

This week’s LCGC International website offerings span AI, food, forensics, and clinical therapy.

Gas chromatography coupled with mass spectrometry and ion mobility spectrometry was used to identify volatile compounds shaped by fermentation time and drying temperature in black tea.

2026 ASMS awards honor advances in native MS, single-cell proteomics, metabolomics, and instrumentation, spotlighting mass spectrometry's scientific impact.

ASMS 2026 highlights a potential paradigm shift in metabolomics, as new evidence suggests many unknown signals are ESI artifacts.