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AI/ML Now: Predicting Reversed-Phase LC Retention Using Ensemble Machine Learning and Open Chromatographic Data (Part Two)

Implementation of the Separation Quality Factor (SQF) in Chromatography Data Systems for Automated Method Evaluation

UHPLC-MS Uncovers Urine Biomarkers of Apple Intake

AI/ML Now: Predicting Reversed-Phase LC Retention Using Ensemble Machine Learning and Open Chromatographic Data (Part One)

LCGC Blog: Building a Career Series That Goes Beyond the Surface

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Optimized preparation and data-independent acquisition (DIA) liquid chromatography–mass spectrometry (LC-MS) detect up to 6500 proteins in laboratory-grown duck.

Directive (EU) 2024/3019 makes drug manufacturers financially responsible for removing pharmaceutical residues from wastewater and introduces stricter, standardized monitoring requirements that are set to increase demand for trace-level analytical expertise.

AOA Dx Chief Scientific Officer Abby McElhinny discusses with LCGC International how the company used high-resolution mass spectrometry-based multi-omics to develop Omira OC, a targeted blood test for early ovarian cancer detection, and how its lipid-based approach is showing promise across endometrial, cervical, and other cancers.

Viktoriia Turkina discusses toxicity prediction for unknown LC–HRMS features using machine learning.

In this final part of "Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor presents a case study of a high-pH separation.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows how processing and storage shape toxins in Nigerian rice.

Ultrahigh-pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) reveals lipid shifts in acne-prone oily skin of young women.

This week, Chromatography Online.com covered the looming chromatography expertise gap, HPLC myths, steroid and biopharmaceutical separations, AI in the laboratory, and new sample extraction tools.

Gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) link tobacco leaf chemistry to cigar taste and burning.

The model context protocol (MCP) layer lets AI run mzmine mass spectrometry workflows; data stays local.

Ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) reveals a chemical imbalance behind alcohol-positive milk.

"Perspectives in HPLC" examines 5 long-held HPLC "rules" (mobile phase filtration, routine buffer use, avoiding pH near an analyte's pKa, defaulting to 4.6-mm columns, and relying on AI for early method development), showing with experimental evidence that each is conditional rather than universally true in modern small-molecule drug testing.

In this ninth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explores the reasons why mobile phase filtration is not needed.

Affinity Chromatography for Biopharmaceutical Analysis: A Mini-Review of History, Principles, and Potential Applications
A review of affinity chromatography methods for biopharmaceutical analysis.

Ultrahigh-performance liquid chromatography–ion mobility–quadrupole time-of-flight mass spectrometry (UHPLC–IM–QTOF MS) reveals seasonal chemical fingerprints in Scottish honey.

























