Latest Content


Antonio Ferracane, University of Messina
1:16
Persistent Analytical Challenges for PAHs
2 days ago
by
Antonio Ferracane
Susanne Boye, Leibniz Institute of Polymer Research
0:42
Looking to the Future of FFF
9 days ago
by
Susanne Boye
Claudia Zielke, Vaxcyte
0:36
FFF and the Importance of Hands-On Lab Expertise
12 days ago
by
Claudia Zielke
Valentina Marassi, University of Bologna
0:38
Will FFF Become Mainstream?
14 days ago
by
Lars Nilsson
Bingchuan Wei, Genentech
1:25
Why You Should Never Fear New Challenges
16 days ago
by
Bingchuan Wei
Valentina Marassi, University of Bologna
0:36
Is FFF the Michelin Star of Analytical Techniques?
19 days ago
by
Valentina Marassi
Bingchuan Wei, Genentech
1:10
How Smart Risks Can Lead to Innovation in Biopharmaceutical Analysis
20 days ago
by
Bingchuan Wei
Bingchuan Wei, Genentech
0:56
Simplified ADC Mass Spec Analysis
22 days ago
by
Bingchuan Wei
Jennifer Field, Oregon State University
0:46
Why PFAS Chemicals Get "Stuck" Near Firefighter Sites
a month ago
by
Jennifer Field
Jennifer Field, Oregon State University
0:44
How Scientists Track Environmental Fingerprints
a month ago
by
Jennifer Field

Survey on Liquid Phase Separation Instruments and Trends

Please help by completing a 10-min survey on liquid phase separation instruments and trends. Enter to win one of five $250 Amazon gift cards—or donate to charity. Responses are confidential; contact info is only for prize notification.

Survey on Liquid Phase Separation Instruments and Trends

Switching from Helium as a Carrier Gas: Can You Afford Not To?

Is It Time For You To Think About It?

Switching from Helium as a Carrier Gas: Can You Afford Not To?

LCGC International April Issue

Read the Latest Cutting-Edge Articles from LCGC

LCGC International April Issue

HPLC 2026 Preview

What to Expect at HPLC 2026

HPLC 2026 Preview

The Column March Issue

A Look at the Latest Applications, Articles, and Interviews from the World of Chromatography

The Column March Issue

Podcasts



All Content

Recent developments in column technology and instrumentation for use in capillary-scale liquid chromatography are discussed. Key motivating factors for the increase in capillary liquid chromatography (LC) usage include a desire for more sustainable analytical methods (including reductions in solvent usage and waste generation) and the need for compact, field-portable systems that can be used in point-of-need settings. To achieve these goals, miniaturization strategies for both column and instrument designs have been required. The impact of these innovations in a variety of application areas—including environmental analysis, forensic testing, and pharmaceutical and biopharmaceutical manufacturing—is described. As the need for greener analytical methods continues to grow, the implementation of low-flow capillary-scale separations will also increase.

Researchers recently developed fluorinated solid phase microextraction (SPME) materials that improve the selective extraction and chromatographic detection of volatile per- and polyfluoroalkyl substances (PFAS) from complex samples. LCGC International spoke to the authors of the paper resulting from this work.