Peer Exchange

GLP-1 peptide therapeutics present mounting analytical challenges for separation scientists—and chromatography and mass spectrometry are rising to meet them. From resolving closely eluting impurities to confirming peptide identity and structure, the field is under pressure to deliver accurate, reliable characterization and quantification across increasingly complex peptide and peptide-conjugate molecules. In this Peer Exchange® from LCGC International, a panel of experts examines the latest solutions and future directions for GLP-1 peptide analysis.

PFAS contamination in environmental samples presents mounting challenges for analytical scientists—and separation science is rising to meet them. From advances in analytical methodologies to evolving regulatory demands, the field is under pressure to deliver accurate, reliable detection and quantification across complex environmental matrices. In this Peer Exchange® from LCGC International, a panel of experts examines the latest solutions and future directions for PFAS monitoring.

PFAS Analysis: Advances, Challenges, and the Road Ahead
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No single analytical technique tells the whole story of a bioconjugate. Learn how experts are integrating advanced separations and multi-detector technologies to unlock the critical quality attributes that drive successful development.

A panel of leading experts convene in an LCGC International Peer Exchange® to examine the current science and regulation around nitrosamines and genotoxic impurities, and what pharmaceutical laboratories must do to stay ahead of an evolving compliance landscape.

Nitrosamines & Genotoxic Impurities in Pharmaceutical Development and Manufacturing
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A recent LCGC International Peer Exchange® brought together academic, industrial, and regulatory experts to assess the growing sophistication of food fraud and where authenticity testing must evolve to meet it.

Food Authenticity and Fraud Detection: A Separation Science Perspective
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As GLP-1 receptor agonists reshape metabolic medicine, leading experts gather in an LCGC International Peer Exchange® to explore the analytical, regulatory, and clinical challenges pharmaceutical laboratories must navigate to keep pace with this fast-moving therapeutic class.

Decoding GLP-1 Therapies from Lab to Clinic
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In this LCGC International Peer Exchange®, a group of experts gather to examine the evolving separation science of oligonucleotide analysis, from the rise of ion-pair reversed-phase HPLC and the roles of ion-exchange and HILIC, to multidimensional chromatography, machine learning applications, and the unique challenges of analyzing larger and higher-order-structure oligonucleotides.

Oligonucleotide Analysis: A Separation Science Perspective
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In this LCGC International Peer Exchange®, a panel of PFAS experts examines the state of separation science for per- and polyfluoroalkyl substances, from persistent analytical challenges like background contamination and detection limits to innovative approaches for quantifying short-chain and non-targeted PFAS, the role of emerging regulatory standards, and the collaborative partnerships driving the field's future.

Hot Topics in PFAS
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In this LCGC International Peer Exchange®, a panel of pharmaceutical analysis experts examines the challenges of nitrosamine detection, from preferred techniques, instrumentation, and sample preparation practices to the analysis of nitrosamine intermediates and reference standards, the sources and reformulation strategies driving compliance, and the evolving regulatory landscape shaping the field.

Emerging Trends in Nitrosamine Analysis for Pharma
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In this LCGC International Peer Exchange®, a panel of experts examine the state of separation science for antisense oligonucleotides (ASOs), from persistent challenges in chemistries and column selection to advanced analytical strategies like 2DLC, the regulatory stance on oligonucleotide enantiomers, and the debate over robustness, reproducibility, and fit-for-purpose separation power shaping the field's future.