OR WAIT null SECS
© 2021 MJH Life Sciences and Chromatography Online. All rights reserved.
© 2021 MJH Life Sciences™ and Chromatography Online. All rights reserved.
April 02, 2021
Preventing cross contamination during pipetting is vital for accurate and reliable results. In order to avoid it you need to be aware of the potential sources.
March 18, 2021
This technical note explores a new trityl-on procedure that minimizes the risk of depurination.
Extraction of oligo therapeutics from biological samples for LC–MS bioanalysis
Using the Clarity OTX extraction protocol vendor recommendations, we have demonstrated its use to develop a method for the extraction of therapeutic oligos from plasma.
This technical note discusses 2' cleavage and RNA sample preparation prior to trityl-on Clarity QSP cartridge or high-throughput purification.
As synthetic oligonucleotide therapeutics traverse the drug-development path, there is an increasing need for TK and PK/PD studies in drug discovery and development.
Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.
This technical note discusses a simple, yet quick and effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit.
Advance your oligonucleotide work, from sample preparation to analysis and purification
To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.