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This installment of Tips & Tricks will provide some helpful pointers to keep
your GPC/SEC system in good shape.

Tips & Tricks: Treating Your GPC/SEC System Properly

With suspect PFAS screening becoming more popular, and the list of known PFAS now in the thousands, novel analytical tools are needed to generate transferable data sets. We highlight key updates here.

Tools for Investigating the Expanding Per- and Polyfluoroalkyl Substances (PFAS) Universe

Online 2D-LC is a powerful—and accessible—tool for analyzing pharmaceutical and biopharmaceutical samples, in both R&D and QC. It’s now easier than ever to develop 2D-LC methods, and they can be run in a fully automated manner.


Minimizing the Risk of Missing Critical Sample Information by Using Two-Dimensional Liquid Chromatography

Is the informing power of separation science without limits?

Curing My Personal Ignorance, One Day at a Time

The fundamental mechanisms of band broadening are usually introduced to students through the van Deemter equation. Dimensional analysis of this equation can give physical meaning to the equation coefficients and enhance our understanding relative to qualitative descriptions. This approach can also guide improvements to future liquid chromatography (LC) column designs.

Liquid Chromatography Column Design and Dimensional Analysis of the van Deemter Equation

Further miniaturization of separations will greatly extend the reach of single-cell proteomics, metabolomics, and lipidomics, but key challenges in instrumentation, column technology, and ionization sources must be addressed.

Let’s Get Small: Miniaturizing Separations for Single-Cell Analysis

This paper provides an overview of some current and emerging physicochemical analytical challenges associated with these sophisticated drug systems and some of the technical advances needed in chromatographic systems to enable their design, development, and manufacture.

Incorporating HPLC as a Multi-Attribute Characterization Technology for Next-Generation Drug Development

As two-dimensional liquid chromatography (2D-LC) becomes more widely used, system suitability tests (SSTs) become even more important.

Development of a System Suitability Test for Two-Dimensional Liquid Chromatography

With a new prototype, we explore how to improve the resolution power and usability of LC–MS instruments for routine analysis in pharmaceutical applications.

Improved Performance of UHPLC–MS Hyphenated Systems

New sample preparation workflows for intact proteins in biological matrices are needed. We hope that others will join in this important field of research.

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