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© 2022 MJH Life Sciences and Chromatography Online. All rights reserved.
© 2022 MJH Life Sciences™ and Chromatography Online. All rights reserved.
September 01, 2022
Non-targeted analysis of small molecules with ambient ionization mass spectrometry (AI-MS) is enabled by new mass spectral libraries and algorithms, such as the inverted library search algorithm (ILSA) developed at NIST.
Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.
Gene therapy vectors in the gigadalton (GDa) regime are beyond the range of conventional mass spectrometry. Charge-detection MS overcomes this limitation.
Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.
In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.
August 01, 2022
An overview of modern approaches to small-molecule drug discovery.
Better sample preparation and miniaturized separations are enhancing these analyses.
Sample preparation and analysis of pharmaceuticals in wastewater present unique challenges. Here, we describe those challenges.
The recruitment of young, talented entrepreneurs within academia and industry is needed to tackle many of the challenges that exist today and that will emerge tomorrow.
Further miniaturization of separations will greatly extend the reach of single-cell proteomics, metabolomics, and lipidomics, but key challenges in instrumentation, column technology, and ionization sources must be addressed.