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Articles

This review article summarizes the results obtained from the combined efforts of a joint academic and industrial initiative to solve the real-life challenge of determining low levels of peptide-related impurities in the presence of the related biologically-active peptide at a high concentration.

Method Development for Reversed-Phase Separations of Peptides: A Rational Screening Strategy for Column and Mobile Phase Combinations with Complementary Selectivity

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Separation Science: The State of the Art: Nontargeted Screening in Environmental Analysis: An Example Showing Migration of Chemicals from Reusable Sports Plastic Bottles into Drinking Water

Webcasts

Webinar Date/Time: Monday, November 28 2022 at 11 am EDT


 

Trace impurities in Pharmaceutical Products: Nitrosamines and beyond

How to lower the limits of quantitation as the regulatory landscape continues
to evolve.

Lowering Limits of Quantitation in LC–MS/MS Analyses for Food Safety and Environmental Applications

Non-targeted analysis of small molecules with ambient ionization mass spectrometry (AI-MS) is enabled by new mass spectral libraries and algorithms, such as the inverted library search algorithm (ILSA) developed at NIST.

Algorithms and Databases: Unlocking Non-Targeted Screening of Small Molecules with Ambient Ionization Mass Spectrometry

Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.

What’s Your Workflow? Non-Targeted Analysis of Water Samples

Gene therapy vectors in the gigadalton (GDa) regime are beyond the range of conventional mass spectrometry. Charge-detection MS overcomes this limitation.

Charge Detection Mass Spectrometry: Analysis of Gene Therapy Vectors

Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.

Turning Metabolomics Data Processing from a “Black Box” to a “White Box”

In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.

Nontargeted Screening for the Verification of Allergenic Ingredients and Perfume Authenticity by GC-ecTOF-MS

An overview of modern approaches to small-molecule drug discovery.

Mass Spectrometry | Topics