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Modern ion mobility–mass spectrometry (IM–MS) is a key separation technology for detailed molecular characterization studies and also as part of emerging data acquisition strategies for demanding small molecule and several applications. Here is what you need to know.

Ion Mobility–Mass Spectrometry (IM–MS): Enhancing Performance of Analytical Methods

Mary Ellen McNally, PhD, is a Global R&D Fellow at the Stine Research Center for FMC Corporation. She has been widely recognized for her contributions to the field of separations, particularly supercritical fluid chromatography (SFC), and for applications of chromatography and mass spectrometry to industrial problems. We recently spoke to her about her work using mass spectrometry to solve problems in the agricultural industry.

Solving Challenges in the Agricultural Industry Using Separation Science: An Interview with Mary Ellen McNally

Kevin A. Schug is a Full Professor and Shimadzu Distinguished Professor of Analytical Chemistry in the Department of Chemistry & Biochemistry at The University of Texas (UT) at Arlington. He joined the faculty at UT Arlington in 2005 after completing a Ph.D. in Chemistry at Virginia Tech under the direction of Prof. Harold M. McNair and a post-doctoral fellowship at the University of Vienna under Prof. Wolfgang Lindner. Research in the Schug group spans fundamental and applied areas of separation science and mass spectrometry. Schug was named the LCGC Emerging Leader in Chromatography in 2009, and most recently has been named the 2012 American Chemical Society Division of Analytical Chemistry Young Investigator in Separation Science awardee.

The petroleum industry appears to be making significant strides to improve the environmental stewardship and operational efficiency of energy production by implementing new technologies and capitalizing on previously wasted resources like produced water and flare gas. Nonetheless, many questions still remain about the management of aging or even abandoned infrastructure because abandoned production wells provide a potential for undocumented contamination events.

The LCGC Blog: The Analytical Arsenal for Point Source Attribution

Analysis of extractables and leachables (E&L) from plastic packaging is of great importance for pharmaceutical product safety. Accurate and rapid identification of unknown compounds in E&L is often complex and challenging. To address this challenge, we demonstrate a quick method for oligomer determination using LC–QTOF-MS.

A Quick Approach to Screen Oligomers from Extractables Studies Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry (LC–QTOF-MS)

Supplementing short pulse lasers with laser postionization increases ionization yields for desorption and ablation of solid samples in mass spectrometry. Here, we give an overview of the mechanisms and technical requirements for molecular photoionization in femtosecond (fs) laser desorption postionization mass spectrometry (LDPI-MS).

Laser Desorption Postionization Mass Spectrometry

Using ion mobility, analytes that have the same molecular mass can be separated by their shape, centers of mass, and collision cross section, but challenges such as ion loss can still occur. A new development in ion mobility separation, high-resolution ion mobility (HRIM), addresses such problems, and is particularly well suited to challenging applications, such as glycosylation monitoring of biological drugs and vitamin D analysis.

Six Key Differentiators Between Liquid Chromatography and High-Resolution Ion Mobility

Two-dimensional liquid chromatography (2D-LC) allows much greater resolution of peaks than is possible in a classical single dimensional separation. For the next development in separations, we employed 2D-LC in two highly orthogonal dimensions of separation with four mass spectrometers for detection, with parallel detection in each dimension. We have further broken ground by using three dimensions of separation with four mass spectrometers, using two parallel second dimensions.

Breaking the Rules: Two- and Three-Dimensional Chromatography with Four Dimensions of Mass Spectrometry

Decomposing animal tissue releases volatile organic compounds (VOCs), of interest in forensic science. We describe the use of GC×GC–qMS/FID retrofitted with a reverse fill/flush (RFF) flow modulator for analyzing these VOCs in a tropical climate.

Investigating Decomposition Odor in a Tropical Climate by Comprehensive Two-Dimensional Gas Chromatography (GC×GC) Coupled with Mass Spectrometry (MS) and Flame Ionization Detection (FID)

Highlights of the new high-performance liquid chromatography, mass spectrometry, and chromatography data systems introduced over the past year.

New HPLC, MS, and CDS Products Introduced in 2020–2021: A Brief Review

We present our annual review of new products in gas chromatography, introduced between spring 2020 and spring 2021.

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