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This article quantifies the progress in speed and efficiency that has been made in the area of liquid chromatography (LC) over the past 50 years. After a decade of groundbreaking advances in the 1970s, the progress in chromatographic performance over the ensuing four decades (1980–now) follows Moore’s law relatively closely. This is characteristic of technological fields that are of an evolutionary nature (that is, driven by the need for better performance).

Moore’s Law in Liquid Chromatography: An Overview of 50 Years of (U)HPLC

A series of theoretical, visualization, and simulation tools that are used to improve the structure and chemistry of the next generation of liquid chromatography (LC) columns is briefly reviewed.

Next Generation of Chromatographic Columns and Systems: From Theories to Possible Future Practices

This is the third in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2019 conference in Milan, Italy, from 16–20 June.

A Universal Generic (U)HPLC Reversed-Phase Gradient Method for Quality Assessments of Multiple Small Molecule Drugs

The effect of dwell volume on chromatographic selectivity can be successfully modelled using retention prediction software. Hence, the robustness of reversed-phase LC gradient methodologies, with respect to dwell volume, can be conveniently assessed.

Understanding How Dwell Volume Can Affect Selectivity in Reversed-Phase Gradient Chromatography

What are the most useful chromatography books on your bookshelf? What are the most useful web-based resources (such as websites, downloadable documents, videos) about separation science? What are the most useful tools supporting your work (such as calculators and simulators)? In this installment, Dwight Stoll compiles input from the separation science community (both individuals and vendors) to guide you to the resources that people find most useful.

Resources for LC Practitioners in 2017: What’s on Your Bookshelf and in Your Web Browser?

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.


The Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs

The three-day Chromatographic Society meeting was held on Monday 15th until Wednesday 17th May 2017 and was hosted by Pfizer at Discovery Park in Sandwich, Kent, UK. This comprehensive symposium featured oral presentations from leading practitioners of supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC) from throughout Europe. Some of the latest innovations and applications were described and the lectures were augmented and supported by a comprehensive exhibition of instrumentation and consumables. The attendees gained insight into practical application of these techniques across a variety of industries-particularly the pharmaceutical industry. As was anticipated, in a comprehensive programme there was a significant focus on SFC for chiral and preparative-scale analysis.

The Chromatographic Society Meeting Report: Supercritical and Ultrahigh-Pressure Chromatography: Part 2

John shares lessons learned from his more than three decades of teaching liquid chromatography practitioners and helping them solve their problems.

What LC Troubleshooting Has Taught Me

This instalment in our series on ultrahigh-pressure liquid chromatography (UHPLC) highlights its benefits in fast analysis, high-resolution separations, high performance liquid chromatography (HPLC) method development, reduced solvent and sample usage, and enhanced sensitivity and precision performance.

UHPLC, Part 2: Benefits

In this three-part series, we assess how UHPLC evolved into a modern platform. We start by examining the most important features common to most commercial instruments.

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